Key Features

Different doses of Avaforce

Features of Avaforce Medication

• Medications like Avaforce 50 mg and Avaforce 100 mg contains Avanafil as an active ingredient.
• These medications are being used to treat Erectile Dysfunction.
• These medications have similar mechanism of action.
• These typically takes 60-180 minutes after oral administration.

How does Avaforce work? 

Avaforce operates by inhibiting the action of PDE5, an enzyme that degrades cyclic guanosine monophosphate (cGMP). cGMP is a major factor in the erectile process, as it causes smooth muscle relaxation within the penis, enhancing blood flow. By inhibiting PDE5, avanafil facilitates an accumulation of cGMP, inducing long-lasting erection.

• Sexual arousal triggers the release of nitric oxide in the penis.
• Nitric oxide increases the levels of cyclic guanosine monophosphate (cGMP).
• cGMP relaxes the smooth muscles in the penis, allowing blood vessels to dilate and increasing blood flow.

Duration of Action: 6 hours 

Uses of Avaforce

• Erectile Dysfunction: It is indicated for the treatment of ED in adult males, enhancing blood flow to the male genitalia.
• Enhances Sexual Function: Aids men in attaining and sustaining an erection upon sexual stimulation.

Dosage

• Starting dose of Avaforce is 50 mg and can be extended up to 100 mg depending on the requirement within an interval of 24 hours.
• It can be taken 1-3 hours before sexual activity. 

Dosage of Avaforce 

• Avaforce 50 mg
• Avaforce 100 mg 

Side effects of Avaforce

• Nausea
• Flushing
• Headaches
• Back pain
• Sore Throat 

Interaction of Avaforce 

• CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): Increase avanafil levels, CYP3A4 inhibitors can retard the metabolism of avanafil, with consequent higher levels and a greater risk of adverse effects.
• CYP3A4 Inducers (e.g., rifampicin, bosentan): Reduce avanafil concentration, CYP3A4 inducers may speed up avanafil metabolism, weakening is efficacy.
• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Severe hypotension, Tadalafil may enhance the blood pressure-lowering effects of nitrates and cause potentially hazardous reductions in blood pressure.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Increase risk of hypotension, avanafil has the potential to increase alpha-blockers hypotensive effects.
• Grapefruit: Grapefruit and grapefruit juice may raise levels of avanafil in the blood, which could result in higher side effects.
• Alcohol: Drinking a lot of alcohol with avanafil might cause side effects to be greater, such as dizziness, headache, and low blood pressure. Taking moderate alcohol is recommended.
• People with heart disease or high blood pressure might have increased risks when using avanafil.
• Abnormal liver or kidney function may change the metabolism and elimination of avanafil, requiring dose modification.
• Diseases such as retinitis pigmentosa might be worsened by avanafil.
• Priapism, a lasting erection of the penis, may occur with avanafil in some patients. 

Therapeutic Suggestions

• Adjustments in dose can be made when avanafil is administered with CYP3A4 inhibitors or inducers.
• Concomitant use should be avoided of avanafil with nitrates or other PDE5 inhibitors.
• Blood pressure should be monitored when avanafil is administered with antihypertensives or alpha-blockers.
• Alcohol should be consumed in limited amounts to prevent side effects. 

Pharmacokinetics 

• Absorption: Avanafil is absorbed rapidly, with a median time to maximum plasma concentration (Tmax) of approximately 30-45 minutes.
• Distribution: Avanafil is approximately 99% consist of plasma protein.
• Metabolism: Avanafil is metabolized primarily by the CYP3A4 enzyme. 

Precautions:

• Avoid alcohol while taking the Avaforce medications.
• Let your physician know if you have any heart, Kidney conditions, like Kidney or liver disease, heart failure, coronary artery disease, or recent myocardial infarction.
• If you have a prolonged erection (over 4 hours), seek immediate medical care. 

Conclusion

Avaforce 100 mg contains Avanafil as an active ingredient that has been identified to be a promising treatment for ED. Avanafil was approved for the treatment of ED in the US and Europe in 2012 and 2013. This drug also has the advantages of rapid onset of action (Tmax 35 min) and short half-life (< 1.5 h) compared to other PDE5 inhibitors. It works by mediating the breakdown of cyclic guanosine monophosphate (cGMP), inducing smooth muscle relaxation in the corpus cavernosum of the penis, increasing local blood flow, and leading to erection. It is recommended to consult a medical professional prior using medications.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3498142/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10362898/