Key Features

Avanair Medication

Features of Avanair Medication

• Medications like Avanair 100 mg contains Avanafil as an active ingredient.
• These medications are being used to treat Erectile Dysfunction.
• These medications have similar mechanism of action.
• These typically takes 60-180 minutes after oral administration.

How does Avanair work? 

• Sexual arousal triggers the release of nitric oxide in the penis.
• Nitric oxide increases the levels of cyclic guanosine monophosphate (cGMP).
• cGMP relaxes the smooth muscles in the penis, allowing blood vessels to dilate and increasing blood flow. 

Duration of Action: 6 hours 

Uses of Avanair 100 mg

• Erectile Dysfunction: Avanair is indicated for the treatment of ED in adult males, enhancing blood flow to the male genitalia.
• Enhances Sexual Function: Aids men in attaining and sustaining an erection upon sexual stimulation. 

Dosage

• Avanair can be taken 30 minutes prior to sexual relations.
• Make sure not to exceed the dosage of Avanair 100 mg per day.

Side effects

• Nausea
• Flushing
• Headaches
• Back pain
• Sore Throat

Avanair is well-tolerated, with most users experiencing minimal side effects that can vary in severity and impact from person to person. But it is recommended to consult a medical professional prior using any of these medications. 

Interactions 

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Severe hypotension, Tadalafil may enhance the blood pressure-lowering effects of nitrates and cause potentially hazardous reductions in blood pressure.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Increase risk of hypotension, avanafil has the potential to increase alpha-blockers hypotensive effects.
• Grapefruit: Grapefruit and grapefruit juice may raise levels of avanafil in the blood, which could result in higher side effects.
• Alcohol: Drinking a lot of alcohol with avanafil might cause side effects to be greater, such as dizziness, headache, and low blood pressure. Taking moderate alcohol is recommended. 

Pharmacokinetics 

• Absorption: The drug is readily absorbed, with a median time to the maximum plasma concentration (Tmax) of 30 to 45 minutes when taken fasting.
• Metabolism: The metabolism of Avanafil involves the enzyme Cytochrome P450 3A4 (CYP3A4), which metabolizes.
• Elimination: Half-life value (T1/2) for avanafil varies from 1 hour 10 minutes to 11 hours. 

Clinical Trial Safety & Efficacy

• Efficacy: Avanafil produced significant improvements in erectile function in patients with ED, as assessed by the International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) questionnaires.
• Safety: Generally, the drug was tolerated well with headache, flushing, and nasopharyngitis as the common side effects of avanafil.
• Dose Response: The 100 mg and 200 mg doses of avanafil led to noteworthy improvements in IIEF-defined erectile function versus placebo. 

Precautions

• Avoid alcohol while taking the Avanair medications.
• Let your physician know if you have any heart, Kidney conditions, like Kidney or liver disease, heart failure, coronary artery disease, or recent myocardial infarction.
• If you have a prolonged erection (over 4 hours), seek immediate medical care. 

Conclusion

Avanafil has proven to be a safe pharmacological agent for managing ED with a quick onset of action and desirable pharmacokinetic profile. However, the initial dosage is advised to be 100 mg, which may be increased to 200 mg depending on efficacy and tolerability. It is recommended to consult a medical professional or a doctor prior taking the medications as this may contains some side effects and may show interactions that can vary from person to person.

References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3433322/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3498142/