Key Features

Different doses of Carefill

• Super Carefill
• Carefill 60 mg
• Carefill 40 mg
• Carefill 20 mg
• Carefill 5 mg

Features of Carefill Medication

• Medications like Carefill 5 mg, Carefill 20 mg, and Carefill 40 mg, Carefill 60 mg and Super Carefill contains Tadalafil as an active ingredient.
• These medications are being used to treat Erectile Dysfunction, Benign Prostatic Hyperplasia and Pulmonary Arterial Hypertension.
• These medications have similar mechanism of action.
• These typically takes 60-180 minutes after oral administration. 

How does Tadalafil Work?

Tadalafil inhibits the Phosphodiesterase Type 5 enzyme, that leads to nitric oxide release, and results into smooth muscle relaxation.

• Inhibition of PDE5 enzyme: This Phosphodiesterase Type-5 enzyme enhances cyclic guanosine monophosphate (cGMP) levels by causing dilation of blood vessels in the penis.
• Increasing nitric oxide release: It leads to nitric oxide release, with sexual excitement, release of nitric oxide is intensified, leading to elevated levels of cGMP.
• Smooth muscle relaxation: Tadalafil reduces symptoms of BPH by enhancing urine flow in bladder and prostate gland.

Dosage

• Starting dose of Carefill is 5 mg and can be extended up to 40-60 mg depending on the requirement within an interval of 24 hours.
• It can be taken 1-3 hours before sexual activity. 

Applications of Carefill

Tadalafil is most commonly prescribed for:

• Erectile Dysfunction: Managing ED in men, facilitating achieving and sustaining erections.
• Benign Prostatic Hyperplasia: Managing symptoms such as urgency to urinate, poor stream, and incontinence.
• Pulmonary Arterial Hypertension: Decreasing pulmonary blood vessel pressure, enhancing exercise capacity. 

Benefits of using Carefill medication

• Long duration of action up to 36 hours, enabling more spontaneity.
• Enhanced erectile function, more confidence, and satisfaction.
• Enhanced urine flow and lessened symptoms for Benign Prostatic Hyperplasia.

Side effects 

• Headache
• Muscle pain
• Flushing
• Nausea
• Back pain
• Dizziness

Interactions

• CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): Increase Tadalafil levels, CYP3A4 inhibitors can retard the metabolism of Tadalafil, with consequent higher levels and a greater risk of adverse effects.
• CYP3A4 Inducers (e.g., rifampicin, bosentan): Reduce tadalafil concentration, CYP3A4 inducers may speed up Tadalafil metabolism, weakening is efficacy.
• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Severe hypotension, Tadalafil may enhance the blood pressure-lowering effects of nitrates and cause potentially hazardous reductions in blood pressure.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Increase risk of hypotension, Tadalafil has the potential to increase alpha-blockers hypotensive effects. 

Clinical Trial (Erectile Dysfunction)

• EndoPAT Device for Endothelial Dysfunction in ED: This trial assesses endothelial dysfunction in young men with vasculogenic ED using EndoPAT before and after daily low-dose phosphodiesterase type 5 (PDE5) inhibitor therapy.
• External Device for Erectile Dysfunction (3D-Erect): This trial tests the safety and feasibility of a non-invasive 3D-printed external penile device to achieve successful and satisfactory sexual intercourse in men with ED. 

Efficacy

• Treatment of BPH: It has been shown that tadalafil is effective in treating lower urinary symptoms (LUTS) in men with BPH. A study has indicated that tadalafil 5mg once daily was effective in improving symptoms and QOL in men with BPH.
• Erectile Dysfunction: It has proven effective in the treatment of erectile dysfunction, with marked improvement in erectile function and satisfaction.
• Combination Therapy: The combined use of tadalafil with other medications such as tamsulosin has been found to be effective in the treatment of BPH and ED.

Precautions

• Inform your physician if you experience a history of heart diseases, including angina or heart failure.
• Tadalafil may reduce blood pressure, so be careful while having Carefill in such condition of hypotension.
• Dose reduction may be required if you suffer from severe kidney or liver impairment.
• Generally, tadalafil is a safe and well-tolerated drug for the treatment of ED and BPH when taken according to directions. But, it is recommended to consult a medical professional prior taking Carefill. 

Conclusion 

Tadalafil in Carefill is a medication that is prescribed for treating conditions like erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. The drug acts by preventing the action of phosphodiesterase type 5 enzyme, thereby increasing the concentration of cyclic guanosine monophosphate, which leads to an increase in blood flow. It has shown promising results for the treatment of erectile dysfunction with a significant increase in erectile function as well as patient satisfaction. The drug’s prolonged half-life allows it to be administered once a day, which makes it a preferable treatment strategy. It is recommended to consult a medical professional prior using medication.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Tadalafil-d3

https://www.ncbi.nlm.nih.gov/books/NBK603743/