It contains Sildenafil Citrate as its active ingredient, which belongs to the class of Phosphodiesterase Type-5 (PDE5) inhibitors.

This medication enhances blood flow to the penis by relaxing the smooth muscles in the penile region, allowing men to achieve and maintain firm erections naturally during sexual stimulation.

Key Features

Different doses of Mahagra

• Mahagra 100 mg
• Mahagra 150 mg
• Mahagra 200 mg

Features of Medication

• Medications like Mahagra 100 mg, Mahagra 150 mg, and Mahagra 200 mg contains Sildenafil Citrate as an active ingredient.
• These medications are being used to treat erectile dysfunction (ED).
• These medications have similar mechanism of action.
• These typically takes 30-60 minutes after oral administration.

How Does It Work?

Mahagra works through a scientifically proven mechanism involving the inhibition of the PDE5 enzyme, which regulates blood flow in the penile tissue.

• PDE5 inhibition: Sildenafil Citrate blocks the PDE5 enzyme responsible for degrading cyclic guanosine monophosphate (cGMP).
• Elevated cGMP levels: This leads to relaxation of the smooth muscles in the corpus cavernosum.
• Increased blood flow: Relaxed blood vessels allow more blood to flow into the penis during sexual stimulation.
• Nitric oxide stimulation: Sexual arousal triggers nitric oxide release, further supporting vasodilation and erection.

By maintaining higher cGMP levels, Mahagra helps men achieve stronger, longer-lasting erections naturally.

Dosage

• The standard starting dose is 100 mg, taken approximately 30–60 minutes before sexual activity.
• Based on individual response, the dosage may be increased to 150 mg or 200 mg under medical supervision.
• Only one tablet should be taken in a 24-hour period.
• It can be taken with or without food, though high-fat meals may delay absorption and onset.

Note: Always use Mahagra as prescribed by your healthcare provider.

Benefits of Using Mahagra

• Promotes and sustains firm erections during sexual activity.
• Enhances sexual confidence and satisfaction.
• Supports overall sexual health and performance.
• Long-lasting effects depending on the dose.

Pharmacokinetics

• Absorption: Rapidly absorbed; peak plasma levels reached within 30–60 minutes.
• Distribution: Widely distributed in body tissues, with a volume of approximately 105 L
• Metabolism: Metabolized primarily by CYP3A4 enzymes in the liver
• Excretion: Excreted mainly through feces (80%) and urine (13%)

Drug Interactions

• Nitrates: Combination can cause dangerous drops in blood pressure (e.g., nitroglycerin, isosorbide mononitrate).
• Alpha-blockers: May increase risk of hypotension (e.g., doxazosin, terazosin).
• Antihypertensives: Can potentiate blood pressure–lowering effects.
• Protease inhibitors: May increase plasma levels of Sildenafil (e.g., ritonavir, saquinavir).
• Macrolide antibiotics: Such as erythromycin and clarithromycin can enhance Sildenafil effects.

Food Interactions

• Grapefruit or grapefruit juice: Increases Sildenafil levels, raising risk of side effects.
• Alcohol: May worsen dizziness, flushing, or fainting; use cautiously.

Disease Interactions

• Cardiac conditions: Avoid in patients with recent myocardial infarction or severe heart failure.
• Liver impairment: Requires medical dose adjustment.
• Kidney impairment: May require lower dose or monitoring.

Side Effects

Common side effects associated with Mahagra include:

• Headache
• Flushing
• Nasal congestion
• Indigestion
• Dizziness

Less common effects: Blurred vision, muscle pain, or prolonged erection (priapism). Seek immediate help if any severe reaction occurs.

Precautions

• Not to be used by individuals taking nitrates or nitric oxide donors.
• Avoid combining with other ED medications.
• Consult your doctor before use if you have cardiovascular issues.
• Alcohol consumption should be limited.
• Not intended for women, children, or adolescents.
• Should only be taken once within a 24-hour period.

Conclusion

Mahagra is a reliable and effective treatment for men experiencing erectile dysfunction. It works by promoting better blood circulation in the penis and enabling a stronger, more sustained erection.
When used responsibly and under a doctor’s supervision, Mahagra can significantly improve sexual performance, confidence, and overall well-being.

References:

• https://pmc.ncbi.nlm.nih.gov/articles/PMC2387281/
• https://doi.org/10.2165/00003495-199957060-00015
• https://pubchem.ncbi.nlm.nih.gov/compound/Sildenafil-Citrate