Key Features

 Different Strength of Priligy

• Priligy 30 mg
• Priligy 60 mg

 Features of Medication

• Medications like Priligy 30 mg, Priligy 60 mg contains Dapoxetine Hydrochloride as an active ingredient.
• These medications are being used to treat erectile dysfunction (ED).
• These medications have similar mechanism of action.
• These typically takes 30-60 minutes after oral administration.

How does Priligy work? 

• Dapoxetine works by raising the level of serotonin in the brain, which in turn is said to delay ejaculation.
• It selectively inhibits serotonin reuptake, increasing serotonin concentration in the synaptic cleft, thereby enhancing serotonin’s action on post-synaptic receptors.

Uses

• Treatment of premature ejaculation in adult males between 18 and 64 years of age.
• Improves ejaculation control: It helps in increasing the time to ejaculation and improves control over ejaculation.
• Meant to be taken as needed for sexual activity.

Dosage 

• Initial dose: 30 mg
• Maximum dose: 60 mg

Priligy is taken by mouth, as needed, 1-3 hours before sexual activity. Minimum dosage is 30 mg/day. 

Side Effects 

• Nausea
• Dizziness
• Headache
• Diarrhea
• Insomnia
• Serotonin syndrome
• Seizures (rare)

Interaction 

• Drug Interaction
• Food Interaction
• Disease Interaction 

Drug Interaction 

• Monoamine Oxidase Inhibitors (MAOIs): Contraindicated due to risk of serotonin syndrome. Examples include phenelzine and tranylcypromine. If MAOIs are stopped, there must be a 14-day washout before starting Priligy.
• Other SSRIs/SNRIs: Concomitant use is contraindicated because of increased risk of serotonin syndrome. Examples include fluoxetine, paroxetine, venlafaxine.
• CYP3A4 Inhibitors: May significantly increase dapoxetine levels, such as ketoconazole, itraconazole, ritonavir, and clarithromycin.
• CYP2D6 Inhibitors: Can increase levels of dapoxetine: e.g., fluoxetine, paroxetine, quinidine.
• Phosphodiesterase-5 inhibitors: May be used concomitantly with caution in individuals with ED and PE: e.g., sildenafil, tadalafil.
• Medications affecting bleeding: May increase bleeding risk when combined with anticoagulants or NSAIDs; examples include warfarin, aspirin, and ibuprofen.
• Lithium and Tryptophan: May increase risk of serotonin syndrome.

Food Interaction

• Alcohol: May increase the risk for adverse reactions including dizziness, somnolence, and altered judgment. May also contribute to the risk of syncope.
• Grapefruit juice: Level of dapoxetine may increase by inhibiting CYP3A4 metabolism.

Disease Interactions

• Cardiovascular Conditions: Priligy should be used cautiously in patients with heart failure, significant cardiac disease, or with any medical history like i.e., syncope faced due to the risk of orthostatic hypotension.
• Psychiatric Disorders: Priligy is contraindicated in patients with a history of mania, severe depression, bipolar disorder, or schizophrenia since it may aggravate these disorders.
• Hepatic impairment: Priligy is contraindicated in patients with moderate to severe hepatic impairment because it is extensively metabolized via the liver.
• Renal Impairment: Priligy should be used cautiously in patients with severe renal impairment, and medical guidance may be required.
• Epilepsy and Seizure Disorders: Priligy should be used cautiously in patients with history of seizures, as SSRIs may lower seizure threshold.

Pharmacokinetics 

• Absorption: Rapid; peak levels may occur within 1-2 hours.
• Metabolism: Hepatic, via CYP2D6 and CYP3A4.
• Elimination: Renal, with a half-life of 1-2 hours. 

Precautions 

• Priligy should be used with caution in patients with cardiovascular disorders and in particular those with risk of orthostatic hypotension.
• Priligy is contraindicated in patients taking MAOIs or other serotonergic medications.
• Patients with a history of psychiatric disorders should be closely monitored for mood changes or suicidal ideation.
• Should be used with caution in patients with bleeding disorders or on anticoagulants.
• Patients should be instructed to avoid alcohol consumption while taking Priligy.

Conclusion

Priligy is a medically tested drug for treating premature ejaculation with demonstrated efficacy and safety under proper medical guidance. As an SSRI developed for on-demand use, it offers a focused approach to PE management. Consultation with a doctor before its intake helps evaluate one’s suitability, absence of contraindications, and achievement of maximum benefit with minimal risks. Follow-up on a regular basis with healthcare providers is required so that modifications are carried out according to effectiveness.

 References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3441133/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3273363/