Budamate 400 Transhaler is a ready to use inhaler that combines two proven medicines budesonide is an inhaled corticosteroid and formoterol which is a long-acting bronchodilator in one convenient device. It is designed for the regular maintenance treatment of asthma and for many adults with Chronic Obstructive Pulmonary Disease (COPD).
Key Features
| About Budamate 400 Transhaler | |
|---|---|
| Drug Class | Respiratory agents |
| Subclass | Inhaled Corticosteroid (ICS) and Long-acting beta2-adrenergic agonist (LABA) |
| Product Details | |
|---|---|
| Composition | Active ingredients:
Inactive ingredients:
|
| Packaging Type | Rotacaps |
| Pack Size | 120 metered doses |
| Dosage | 1 inhalation twice a day |
| Therapeutic class | Anti-asthmatic, COPD management |
| Action Class | Bronchodilator (LABA) + Anti-inflammatory corticosteroid |
| Chemical class | Budesonide, Formoterol fumarate |
| Manufacturer | Lupin Ltd (India) |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| Country of Origin | India |
| Storage | Store at room temperature (20–25°C), away from moisture and direct sunlight |
How does Budamate 400 transhaler work?
- Budesonide (inhaled corticosteroid): Budesonide reduces inflammation in the airways. By calming the immune driven swelling and redness inside the bronchial tubes, it lowers sensitivity and the chance of worsening symptoms. This effect helps keep the airways steadier day to day.
- Formoterol (long-acting beta-2 agonist, LABA): Formoterol relaxes the small muscles that surround the airways. This widening of the airway lets air move in and out of the lungs more freely for many hours after a dose. Formoterol offers fast onset plus prolonged relief, which supports once or twice daily dosing depending on the formulation and doctor’s instructions.
How to use Budamate 400 Transhaler step-by-step
- Read the patient leaflet in the box.
- If your inhaler has a removable cap or a capsule to load, follow the leaflet to prepare it. If it is prefilled, simply remove the mouthpiece cover.
- Breathe out fully away from the device.
- Place the mouthpiece in your mouth and seal with your lips.
- Take a quick, deep breath in while activating the inhaler (or as instructed).
- Hold your breath for 5-10 seconds. Then breathe out slowly.
- Rinse your mouth if your inhaler contains a steroid (rinsing helps reduce the small risk of throat yeast).
- Keep the device clean and store it as instructed.
Uses
- Treatment of Asthma
- Treatment of Chronic obstructive pulmonary disease (COPD)
Dosage
- Packages of Budamate 400 Transhaler usually deliver budesonide 400 mg together with an appropriate dose of formoterol per actuation.
- Check the carton or patient leaflet for exact strength and device instructions.
- Use twice a day.
- It is recommended to use only after consulting a medical professional.
Side effects
- Headache
- Cough
- Throat irritation
- Hoarseness or oral thrush
- Tremor
- Palpitations
- Mild dizziness
Interaction
- Corticosteroids: Concomitant use of other systemic or inhaled steroids may increase the risk of systemic corticosteroid side‑effects (e.g., hyperglycaemia, immunosuppression).
- Beta‑blockers: May antagonize bronchodilator effect of formoterol; may also cause severe bronchospasm in asthmatics.
- Diuretics (thiazides, loop diuretics): May potentiate hypokalaemia caused by formoterol.
- Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants: May potentiate cardiovascular effects of formoterol.
- Xanthine derivatives (theophylline): May increase hypokalaemia and cardiovascular side‑effects.
- Cytokines, including ketoconazole, itraconazole, and ritonavir: May increase the systemic exposure of budesonide via CYP3A4 inhibition.
Pharmacokinetics
- Budesonide: Readily absorbed from lungs, peak plasma levels within 30 min. Undergoes extensive first‑pass metabolism; half‑life approx. 2–3 h. Plasma protein binding approx. 90%
- Formoterol: Rapidly absorbed, peak plasma levels within 5–10 min after inhalation. Half‑life approx. 8-10 h. Metabolized by liver enzymes (CYP2D6, CYP2C19). Excreted mainly in urine.
Precautions
- To be used with caution in patients with cardiovascular disease, hypertension, diabetes, hyperthyroidism, hypokalaemia, or seizure disorders.
- Risk of oral candidiasis; rinse mouth after use.
- Avoid abrupt discontinuation; may cause adrenal insufficiency.
Conclusion
Budamate 400 Transhaler combines an inhaled corticosteroid with a long-acting bronchodilator to offer daily maintenance therapy for many people with asthma and for adults with COPD who need long-term control. Its dual action calming inflammation and opening airways reduces symptoms and can cut the risk of flare-ups. Always use Budamate 400 Transhaler under medical supervision, keep a rescue inhaler for emergencies, and speak to your healthcare provider about any concerns or side effects.
References
https://pmc.ncbi.nlm.nih.gov/articles/PMC2706613/
https://www.ncbi.nlm.nih.gov/books/NBK563201/
FAQ’s
2) How often should I take the Budamate 400 Transhaler?
Follow your doctor’s directions. Many clinicians prescribe once or twice daily dosing depending on symptom severity and the specific device. Check the pack and your prescription.
3) Can I use the Budamate 400 Transhaler for sudden breathlessness?
No, Budamate 400 Transhaler is for ongoing control. Keep a short-acting rescue inhaler (SABA) for sudden attacks.
4) How does Budamate 400 Transhaler work?
Budesonide reduces inflammation in the airways, and Formoterol relaxes the small muscles that surround the airways.
5) Is Budamate 400 Transhaler safe for everyone?
Yes, it is generally safe, but it is recommended to use only after consulting a medical professional.
Daniel Reed –
Combination inhaler that keeps my breathing steady. No big side effects