Spedra 100 mg is an oral drug mainly used to treat erectile dysfunction (ED) in men. It contains Avanafil as the active component, which belongs to the phosphodiesterase type 5 (PDE5) inhibitor class. Avanafil enhances blood flow to the penis upon sexual stimulation, helping men attain and maintain an erection.

Product Details

How Does Spedra 100 mg Work?

Avanafil inhibits the phosphodiesterase enzyme, releasing nitric oxide, which relaxes smooth muscles and vessels, enhancing blood flow to the penis during arousal. The typical duration of action is up to 6 hours.

• Sexual arousal triggers the release of nitric oxide in the penis.
• Nitric oxide elevates cGMP levels, relaxing penile muscles.
• This dilation allows increased blood flow, producing an erection.

Uses of Spedra 100 mg

• Erectile Dysfunction: Enhances penile blood flow to improve erection quality.
• Improves Sexual Function: Helps sustain erections during sexual stimulation.

Dosage

• Take one tablet of Spedra 100 mg about 30 minutes before sexual activity.
• Your doctor may adjust the dosage to 50 mg or 200 mg based on tolerance.
• Do not exceed one dose in 24 hours.

Possible Side Effects

• Nausea
• Flushing
• Headache
• Back pain
• Sore throat

Spedra 100 mg is generally well-tolerated, with most side effects mild to moderate in severity and short-lived.

Efficacy

Both Spedra dosages (100 mg and 200 mg) significantly improved erectile function based on the International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) results.

Pharmacokinetics

Pharmacokinetic interactions can alter a drug’s Absorption, Distribution, Metabolism, or Excretion (ADME), influencing its effects or side effects.

• Absorption: Rapid, with Tmax around 30–45 minutes.
• Distribution: Approximately 99% bound to plasma proteins.
• Metabolism: Primarily broken down by CYP3A4 enzymes.

Interactions

1. Drug interactions
2. Food interactions
3. Disease interactions

Drug Interactions

• CYP3A4 Inhibitors (ketoconazole, ritonavir): May raise Avanafil levels, increasing side effects.
• CYP3A4 Inducers (rifampicin, bosentan): lower Avanafil levels, reducing efficacy.
• Nitrates (nitroglycerin): May cause dangerous drops in blood pressure.
• Alpha-blockers (tamsulosin, doxazosin): Can intensify hypotensive effects.
• Antihypertensives: Additive hypotensive risk with Avanafil.
• Alcohol: May amplify side effects like dizziness or headache.
• Other PDE5 Inhibitors: Increases side effect risks if combined.

Food Interactions

• Grapefruit: Can increase Avanafil concentration and side effects.
• Alcohol: Excessive use may lower blood pressure and cause dizziness.

Disease Interactions

• Men with heart disease or uncontrolled hypertension should use caution.
• Liver or kidney impairment may require dose adjustment.
• Conditions like retinitis pigmentosa may worsen with Avanafil.
• Priapism (erection lasting over 4 hours) requires urgent medical help.

Therapeutic Suggestions

• Adjust dosage if used with CYP3A4 inhibitors or inducers.
• Avoid combining with nitrates or other PDE5 inhibitors.
• Monitor blood pressure when used with antihypertensives or alpha-blockers.
• Limit alcohol intake to minimize side effects.

Precautions

• Avoid alcohol while taking Spedra.
• Inform your doctor of heart, kidney, or liver conditions before use.
• If an erection lasts longer than 4 hours, seek immediate medical attention.

Conclusion

Avanafil is a promising ED treatment with a rapid onset (Tmax ~35 minutes) and short half-life (<1.5 hours). It was approved in the US and Europe between 2012–2013 and functions by enhancing cGMP-mediated smooth muscle relaxation, improving penile blood flow and erection quality. Its safety and rapid action make it a convenient option for many men.

FAQ’s

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3498142/
https://pmc.ncbi.nlm.nih.gov/articles/PMC10362898/