Combihale FF CFC Free 250 Inhaler is a maintenance inhaler used to help people with asthma and chronic obstructive pulmonary disease (COPD) breathe better. It combines two medicines in one device: fluticasone propionate (a steroid) and formoterol fumarate (a long-acting bronchodilator). Together they reduce inflammation and open the airways. This makes breathing easier, cuts cough and wheeze, and lowers the chance of flare-ups.
Key Features
| About Combihale FF CFC Free 250 Inhaler | |
|---|---|
| Drug Class | Corticosteroid and long-acting bronchodilator combination |
| Subclass | Inhaled corticosteroid (ICS) and long-acting beta-agonist (LABA) |
| Product Details | |
|---|---|
| Composition | Active ingredients:
|
| Packaging Type | Inhaler |
| Pack Size | 120 MDI |
| Dosage | 1–2 puffs twice daily |
| Therapeutic class | Respiratory |
| Action Class | Bronchodilator and Anti-inflammatory |
| Chemical class | Corticosteroid and Beta-agonist |
| Manufacturer | Mankind Pharma Ltd |
| Shelf Life | 2–3 years from the date of manufacturing |
| Usages | Treats asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| Country of Origin | India |
| Storage | Store at room temperature below 30°C in a cool and dry place, protected from direct sunlight, moisture, and heat |
How Combihale FF CFC Free 250 Inhaler works
- Fluticasone propionate (ICS): This is an inhaled corticosteroid. It turns down the inflammation inside the airways. With regular use it reduces swelling, mucus, and sensitivity.
- Formoterol fumarate (LABA): This drug relaxes the small muscles around the airways. The airways widen and stay open for many hours. Formoterol acts quickly and lasts long, so it eases breathing for an extended period.
How does the combination work?
The steroid reduces the cause of symptoms (inflammation). The LABA gives sustained bronchodilation. When used together in one inhaler, patients often get better symptom control than with one drug alone. This dual action is the reason fixed-dose inhalers like Combihale FF work well for long-term control.
Uses
Combihale FF CFC Free 250 Inhaler is used mainly as a regular (maintenance) treatment for:
- Asthma (to control persistent symptoms and reduce attacks).
- COPD (when inhaled steroids plus long-acting bronchodilation are appropriate).
Dosage
Combihale FF products are sold as metered-dose inhalers or dry-powder devices. The commonly listed strength is fluticasone propionate 250 mcg + formoterol fumarate 6 mcg per actuation (check your pack for exact strength and device type). Follow your prescriber’s instructions. Do not change dose or stop suddenly without medical advice.
How to use Combihale FF CFC Free 250 Inhaler step-by-step
- Read the patient leaflet that comes with the device.
- Shake the inhaler if required (MDI) and remove the cap. For dry-powder devices, follow the loading instructions.
- Breathe out fully, away from the mouthpiece.
- Put the mouthpiece in your mouth and seal with your lips.
- Breathe in quickly and deeply while pressing the canister or activating the device (follow the device steps).
- Hold your breath for 5–10 seconds, then breathe out slowly.
- If you use more than one puff, wait about 30 seconds and repeat.
- Rinse your mouth after use if advised (helps reduce local steroid side effects).
- Keep the device clean and store at room temperature.
Side effects
- Throat irritation or hoarseness.
- Cough (sometimes right after inhalation).
- Oral thrush (fungal mouth infection) — rinse mouth if told.
- Headache, dizziness, or nausea in some people.
- Tremor or palpitations (from the LABA) in some patients.
Interactions
- Beta-blockers (used for heart disease or anxiety) may blunt formoterol’s effect.
- Other sympathomimetics or anticholinergics may add effects.
- Certain antifungals and HIV protease inhibitors can raise steroid exposure.
Give your prescriber a full list of medicines, including over-the-counter drugs and herbals.
Pharmacokinetics
Most of the medicine acts in the lungs where it is needed. A small amount enters the bloodstream. Fluticasone has low systemic exposure when inhaled, while formoterol provides fast and long bronchodilation. Clinical studies show reliable lung delivery and expected safety when used as directed.
Precautions
Pregnancy & breastfeeding: Use only if clearly needed and after discussion with your doctor.
- Older adults: May be more sensitive to side effects like dizziness.
- Children: Check age approvals on the pack. Many combination inhalers are licensed for older children and adults.
Conclusion
Combihale FF CFC Free 250 Inhaler is a fixed-dose combination inhaler of fluticasone propionate and formoterol fumarate. It works by easing inflammation and keeping airways open. For many adults with asthma or COPD, it improves daily breathing and lowers symptom burden when used as prescribed. It is a maintenance medicine not a rescue inhaler and should be used under medical guidance.
References
https://www.ncbi.nlm.nih.gov/books/NBK542161/
https://pubchem.ncbi.nlm.nih.gov/compound/Fluticasone
Grace Allen –
Doctor suggested it for my long-term asthma. It’s been reliable