Combitide 25 Mcg/125 Mcg Inhaler
Combitide 25 mcg/125 mcg Inhaler is a combination medication containing Salmeterol and Fluticasone Propionate used for the treatment of asthma and chronic obstructive pulmonary disease.
Price range: $122.58 through $290.81
Availability: IN STOCK
Combitide 25 mcg/125 mcg Inhaler is a combination medication containing Salmeterol and Fluticasone Propionate used for the treatment of asthma and chronic obstructive pulmonary disease. Salmeterol relaxes airway muscles, increasing airflow to the lungs and making breathing easier. Fluticasone Propionate also relaxes airway muscles, increasing airflow to the lungs and enhancing breathing.
Key Features
About | |
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Drug Class | Respiratory agents |
Subclass | Corticosteroid and Long-acting beta2-adrenergic agonist (LABA) |
Product Details | |
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Composition | Active ingredients: Salmeterol (25 mcg), Fluticasone Propionate (125 mcg) Inactive ingredients: Lactose monohydrate |
Packaging Type | Inhaler |
Pack Size | 120 metered doses |
Dosage | 2 inhalations twice a day |
Therapeutic class | Bronchodilators and anti-inflammatory agents |
Action Class | Long-acting beta2-adrenergic agonist (LABA) and Inhaled Corticosteroid |
Chemical class | Beta2-adrenergic agonist, Corticosteroid |
Manufacturer | Cipla |
Shelf Life | 2-3 years from the date of manufacturing |
Usages | Treatment of Asthma and COPD |
Country of Origin | India |
Storage | Store at room temperature (15-30°C), away from moisture and direct sunlight |
How it Combitide 25mcg/125 mcg Inhaler Works?
- Salmeterol: A long-acting bronchodilator that relaxes airway muscles, increasing airflow to the lungs and making breathing easier.
- Fluticasone Propionate: A corticosteroid that reduces inflammation and swelling in the airways.
Dosage
- Typically, 2 inhalations twice daily, but your healthcare provider may adjust the dose based on your condition.
- Shake the inhaler well before each use. Rinse your mouth with water after inhalation to prevent oral thrush.
Uses
- Asthma: Long-term management of symptoms such as wheezing, coughing, and breathlessness.
- Chronic Obstructive Pulmonary Disease (COPD): Helps manage symptoms like chest tightness and difficulty breathing associated with chronic bronchitis or emphysema.
Side Effects
- Upper respiratory tract infection
- Headache
- Throat irritation
- Hoarseness and voice changes
- Nausea and vomiting
- Musculoskeletal pain
Interaction
- Ritonavir: Can increase plasma fluticasone exposure, reducing serum cortisol concentrations.
- Other CYP3A4 substrates: Possible interactions, but unlikely to affect efficacy due to low Salmeterol dose.
Pharmacokinetics
- Salmeterol is extensively metabolized by CYP3A4 in the liver.
- Fluticasone propionate is also metabolized but these pathways are not fully specified.
- Studies show no significant interactions affecting efficacy or safety when combined.
Clinical Study
A 12-week study evaluated the efficacy and safety of this combination in persistent asthma patients aged 4-11 years.
Safety
- Systemic corticosteroid effects, particularly if combined with CYP3A4 inhibitors like Ritonavir.
- Potential cardiovascular effects, especially with other medications.
Efficacy
The combination demonstrates significant improvement in asthma symptom control and lung function in persistent cases.
Precautions
- Avoid if allergic to Salmeterol, Fluticasone, or components.
- Use caution with heart rhythm problems or hypertension.
- Monitor immune suppression risks in infections.
- Watch for blood sugar changes in diabetics.
- Consult doctor before use in hyperthyroid patients.
- Use under strict medical supervision particularly in children under 12.
- Rinse mouth after inhalation to prevent fungal infections.
Conclusion
This inhaler effectively manages asthma and COPD symptoms when used correctly under medical guidance. Proper dosing and precautions are essential to minimize side effects and interactions. Regular consultations with healthcare providers ensure optimal management and safety.
FAQ’s
1) What is Combitide 25 mcg/125 mcg used for?
It is used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
2) How does Combitide 25 mcg/125 mcg work?
It relaxes airway muscles with Salmeterol and reduces inflammation with Fluticasone Propionate, improving airflow.
3) What can be the common side effects?
Common effects include infection, headache, throat irritation, voice change, nausea, and muscular pain.
4) Is it safe for everyone?
It is generally safe when used as prescribed; consult your doctor for personalized advice.
5) Can I use it during an asthma attack?
No, it is for maintenance therapy and not for immediate relief during an attack. Use prescribed emergency inhalers for attacks.
References
Select Inhaler | 3 Inhaler, 6 Inhaler, 9 Inhaler |
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Brandon Hughes –
Milder strength, but works fine for daily control. Easy to inhale