INDIGO – Sildenafil Citrate 100mg Oral Lingual Strips

Oral lingual strips are thin, dissolvable films that contain medication, which is absorbed through the tongue and mouth tissues. Indigo Oral Lingual Strips containing Sildenafil Citrate are used to treat erectile dysfunction (ED). Sildenafil Citrate is a phosphodiesterase type 5 (PDE5) inhibitor. The oral lingual strips are designed for rapid dissolution and absorption through the tongue and mouth tissues, allowing for quick onset of action.

 Key Features

 How does Indigo Oral Lingual strips work?

• Relaxing blood vessels in the penis, increasing blood flow.
• Inhibiting PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP).
• Increasing cGMP levels, leading to smooth muscle relaxation and vasodilation.
• Facilitating erection in response to sexual stimulation.

Usage

• Place one strip on the tongue.
• Allow it to dissolve completely, usually within 15-30 seconds.
• Do not chew, swallow, or drink water while the strip is dissolving.
• Take as needed, about 30 minutes to 1 hour before sexual activity.
• Sexual stimulation is required for the medication to work.

Uses

• Erectile dysfunction (ED).
• Pulmonary arterial hypertension (PAH).

What are Lingual Strips?

Lingual strips are thin, dissolvable strips that contain medication and are absorbed directly into the bloodstream via the tongue and mouth tissues.

How do Lingual Strips Work?

1. Place the strip under your tongue.
2. The strip dissolves, releasing the medication.
3. The drug is absorbed into the bloodstream.

Advantages of lingual strips

1. Fast absorption and onset of action
2. Convenient and easy to use

• No water needed
• Discreet and portable

Common Uses of Lingual Strips

• Pain management Anxiety relief and stress reduction.
• Erectile dysfunction, as we discussed earlier with Sildenafil Citrate Other conditions where rapid absorption is beneficial.

 Dosage

• Typical starting dose: 25-50 mg as needed.
• Maximum dose: 100 mg per day.

Side Effects 

• Headache
• Flushing
• Nasal congestion
• Dizziness
• Nausea
• Vision changes
• Diarrhea
• Priapism

Interactions

• Nitrates (e.g., nitroglycerin): contraindicated.
• Alpha-blockers (e.g., doxazosin): may cause hypotension.
• Protease inhibitors (e.g., ritonavir): may increase sildenafil levels.
• Grapefruit juice: may increase sildenafil levels.
• Other PDE5 inhibitors: not recommended.

Pharmacokinetics

• Rapid absorption through the mucous membranes.
• Peak levels reached within 30-120 minutes (median 60 minutes).
• Half-life: 4-5 hours.
• Metabolized by liver enzymes (CYP3A4 and CYP2C9).
• Excreted through the feces (80%) and urine (13%).

Precautions

• Seek medical evaluation before using sildenafil if you have known cardiovascular disease, recent stroke or myocardial infarction, severe hypotension or uncontrolled hypertension, or significant arrhythmia. Sexual activity itself can stress the heart; sildenafil can add vascular effects.
• Inform your clinician about all medicines, especially nitrates, protease inhibitors, some antifungals, certain antibiotics, alpha-blockers, and other ED medications.
• Stop use and seek urgent medical advice if sudden loss of vision in one or both eyes or sudden hearing loss occurs. These are rare but reported events.

Conclusion

 Sildenafil Citrate oral lingual strips can effectively treat ED, but use with caution and under medical supervision, especially with underlying medical conditions or taking other medications. Oral lingual strips can rapidly alleviate symptoms of a number of conditions. However, caution should be exercised, and medical supervision is recommended, especially in patients with other medical conditions or those on other medications. Consult a healthcare professional for guidance on safe use and potential interactions.

 References

https://www.ncbi.nlm.nih.gov/books/NBK558978/
https://pmc.ncbi.nlm.nih.gov/articles/PMC2699643/

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