Levolin 50 Mcg (200mdi) Inhaler

Levolin 50 MCG is an inhalation aerosol that includes Levosalbutamol as an active ingredient. It is a short-acting beta2-adrenergic agonist or SABA used to relieve bronchospasm and symptoms associated with asthma and COPD.

Key Features

How Does Levolin 50 mcg Work?

Levosalbutamol acts by stimulating the beta2-adrenergic receptors in the lungs, which leads to relaxation of the smooth muscle of airways, promoting bronchodilation and making it easier to breathe. The overall effect of Levolin 50 MCG lasts for 4-6 hours.

Usages

• Asthma relief: Quick relief of bronchospasm and associated symptoms of asthma.
• Chronic obstructive pulmonary disease (COPD) relief: Relief of bronchospasm and symptoms associated with COPD.

Dosage

• 1-2 puffs as required, not more than 4-6 puffs in 24 hours.
• The inhaler must be shaken well prior to use, then inhaled deeply, and held for 10 seconds.

Side Effects

• Tremors
• Nervousness
• Headache
• Limb numbness
• Dizziness
• Cough
• Palpitations

Interaction

Levolin 50 MCG may interact with:

• Beta blockers: May decrease the effectiveness of Levosalbutamol
• Other sympathomimetic agents: May increase the risk of cardiovascular effects
• Monoamine Oxidase Inhibitors: May increase the risk of cardiovascular effects.

Pharmacokinetics

• Absorption: Readily absorbed following inhalation.
• Metabolism: Metabolized in the liver.
• Excretion: Excreted in urine.

Levolin 50 mcg Inhaler interacts with

• Beta blockers: This may decrease the effectiveness of Levosalbutamol.
• Other anticholinergic agents: May increase the risk of anticholinergic side effects.
• Monoamine oxidase inhibitors (MAOIs): May increase the risk of cardiovascular effects.

Pharmacokinetics

• Absorption: Readily absorbed following inhalation
• Metabolism: Levosalbutamol is metabolized in the liver, while Ipratropium Bromide is minimally metabolized.

Safety

• Common side effects include dry mouth, dizziness, headache, tremors, and cough.
• Serious side effects include paradoxical bronchospasm, cardiovascular effects, and immediate hypersensitivity reactions.
• Should be used with caution in patients with cardiovascular disorders, hypertension, diabetes, or thyroid disorders.

Efficacy

• Levolin Inhaler relieves bronchospasm quickly, with the onset of action of levosalbutamol being rapid within 5-15 minutes.
• The use of ipratropium bromide in combination with levosalbutamol is more effective than using either medication alone, increasing the degree of bronchodilation and improving respiratory function.

Clinical Trial

• Clinical trials have established Levolin Inhaler as effective and safe in the management of symptoms of asthma and COPD.
• Studies have shown that Levolin Inhaler is effective in managing pediatric asthma and provides quick relief from bronchospasm.
• Apart from this, the safety and efficacy of Levolin Inhaler have been established in patients with COPD, for whom its benefits include improvement in lung function and reduction of symptoms.
• Several ongoing and completed trials are still evaluating the safety and efficacy of Levolin Inhaler in various patient groups.

Precautions

• Use with caution in patients with cardiovascular disease, including hypertension or heart failure.
• Administer cautiously in diabetic patients, as Levosalbutamol can increase the blood levels of glucose.
• Use with caution in patients with hyperthyroidism.

Conclusion

Levolin 50 MCG is indicated for the relief of bronchospasm and symptoms associated with asthma and COPD. Generally safe, the medication should be taken as per prescription regarding dosage and usage to minimize side effects and derive maximum benefits.

References

https://pubmed.ncbi.nlm.nih.gov/18031154/

https://pubmed.ncbi.nlm.nih.gov/17337829/

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