Lotel Eye Ointment 5 gm is a corticosteroid ointment containing loteprednol etabonate, formulated to treat inflammation and pain in the eyes after surgery or due to allergy and infection. It reduces ocular swelling by blocking chemical signals responsible for inflammation, providing effective relief with minimal systemic absorption.
Key Features
| About Lotel 5 gm Eye Ointment | |
|---|---|
| Drug Class | Ophthalmic Steroid |
| Subclass | Corticosteroids |
| Product Details | |
|---|---|
| Composition | Active ingredient:Â Loteprednol etabonate (5 gm) Inactive ingredients:
|
| Packaging Type | Tube |
| Pack Size | 5 gm |
| Dosage | Apply a small amount (about 1–2 inch) to affected eye 2–3 times daily |
| Therapeutic Class | Anti-inflammatory |
| Action Class | Blocks prostaglandins, reducing inflammation and pain |
| Chemical Class | Glucocorticoids |
| Manufacturer | Ajanta Pharma Ltd |
| Shelf Life | 2–3 years from date of manufacturing |
| Usages | Treats post-operative inflammation and pain, relieves swelling, itchiness, redness due to infection or allergy |
| Country of Origin | India |
| Storage | Store at room temperature; use within 4 weeks of opening; discard if not used within this period |
How does Lotel Eye Ointment work?
Loteprednol etabonate suppresses production of prostaglandins and inflammatory mediators, decreasing swelling, redness, and discomfort in the eye. It binds to corticosteroid receptors and inhibits phospholipase A2, preventing the formation of inflammatory chemicals.
- Suppresses prostaglandins and other inflammatory mediators
- Inhibits inflammation, swelling, redness
- Relieves symptoms like itching, burning, and discomfort
Mechanism of action:
- Binds corticosteroid receptors
- Inhibits phospholipase A2, reducing inflammation
Usage
- Post-surgical inflammation and pain
- Allergic or infectious swelling, redness, itchiness
Dosage
Insert about a ½ inch ribbon into the conjunctival sac(s) four times daily, starting 24 hours after surgery for first 2 weeks or as directed by your doctor.
Side Effects
- Eye irritation
- Blurred vision
- Eye pain
- Sensitivity to light
- Eye discharge
Interactions
- May interact with other eye preparations
- Minimal systemic interactions due to limited absorption
- Possible specific interactions:
- Voriconazole
- Itraconazole
- Clarithromycin
- Smallpox vaccine
- Bromfenac
Pharmacokinetics
- Minimal systemic absorption after topical use
- Distributes in blood cell components
- Metabolized slowly in the liver
- Eliminated mainly via bile/feces as inactive metabolite PJ-90; half-life ~2.8 hours
- Strong protein binding restricts systemic side effects
Precautions
- Use as prescribed
- Avoid tube tip contamination
- Wear contact lenses only if advised by doctor
- Watch for infection or worsening symptoms
Conclusion
Lotel Eye Ointment 5 gm is an effective corticosteroid for inflammation and pain relief in the eye, intended for use only under medical guidance according to the prescribed dosage and precautions.
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7482125/
- https://pubchem.ncbi.nlm.nih.gov/compound/Loteprednol-Etabonate
Ashley Rivera –
Prescribed for inflammation after surgery. It felt soothing, though greasy. Did the job well