Omnacortil 40 Mg Tablet

Omnicortil 40 mg is a corticosteroid medication derived from prednisolone; hence, it belongs to the synthetic glucocorticoid class. It is used to treat inflammatory and autoimmune diseases such as asthma, skin allergies, allergic reactions, arthritis, lupus, eczema, psoriasis, dermatitis, uveitis, and conjunctivitis.

Key Features

How does Omnacortil Work?

• Glucocorticoid receptor binding: Prednisolone binds to glucocorticoid receptors inside the cells and affects gene expression and protein synthesis.
• Reduction of inflammation: This involves inhibition of pro-inflammatory cytokines and enhancement of anti-inflammatory cytokines.
• Immune suppression: Prednisolone is an immunosuppressive drug that decreases the inflammation and injury of body tissues.

Uses

Use to treat allergic reactions include severe allergic reactions, anaphylaxis, and angioedema.

• Asthma: severe asthma exacerbations, chronic asthma
• Rheumatic disorders: rheumatoid arthritis, lupus, and other autoimmune disorders.
• Skin conditions: Severe skin diseases like eczema, psoriasis, and dermatitis.
• Eye conditions: Inflammatory eye conditions such as uveitis and conjunctivitis.
• Organ transplantation: Prevention of rejection of organ transplant patients.
• Other conditions: Some kinds of anemia, leukemia, lymphoma.

Dosage

• Adults: Usually 5 to 60 mg daily, depending on what is being treated. The precise dose needs to be adapted to each individual according to how ill they are and how they react.
• Children: The dosage is based on the weight of the child and the severity of the condition; it can only be administered under the guidance of a pediatrician.
• Administration: Oral administration, preferably with food to prevent stomach upset.
• Tapering: It is advisable to taper it slowly while stopping after a prolonged period to prevent adrenal insufficiency.

Side Effects

• Increased appetite
• Weight gain
• Mood swings
• Insomnia
• Increased blood pressure
• Elevated blood sugar levels
• Osteoporosis
• Cataracts
• Increased susceptibility to infections

Interactions

• Other corticosteroids: Taking them together can increase systemic side effects.
• Anticoagulants (such as warfarin): They may alter the way blood clots, so monitor your INR closely.
• Antidiabetic drugs: Prednisolone increases blood sugar, so the dose may have to be adjusted.
• Live vaccines: The chance of becoming infected might be higher; steer clear of taking live vaccines during treatment.
• Certain antibiotics and antifungals will change the efficacy of prednisolone by influencing its metabolism.

Pharmacokinetics

• Absorption: Prednisolone is rapidly absorbed from the gastrointestinal tract after oral administration.
• Distribution: Widely distributed throughout the body; binds extensively to plasma proteins.
• Metabolism: This is primarily metabolized in the liver by the hepatic enzymes.
• Excretion: Eliminated mainly through urine as metabolites.

Efficacy

• Anti-inflammatory effects: Reduces inflammation, which helps with arthritis, asthma, and skin problems.
• Immunosuppressive effects: This changes the immune system in ways that help control autoimmune diseases like lupus and rheumatoid arthritis.
• Rapid action: Often produces noticeable relief within hours to days depending on condition severity.

Safety

• Frequent side effects: Increased appetite, Weight gain, Mood swings or irritability, Insomnia, and Fluid retention.
• Less frequent but serious hazards: Immunosuppression and increased susceptibility to infections, Gastrointestinal issues such as ulcers or bleeding, Hypertension (high blood pressure), hyper glycemia (elevated blood sugar), Osteoporosis (bone weakening), Cataracts or glaucoma (with prolonged use), and Adrenal suppression.
• Contraindications: Fungal infections, Active or latent tuberculosis, and Known hypersensitivity to prednisolone or other corticosteroids

Precautions

• Pregnancy and lactation: Consult a doctor before using, as corticosteroids can affect fetal development or pass into breast milk.
• Infections: May obscure or worsen infections; monitor closely.
• Diabetes: Blood sugar levels can rise; monitor regularly.
• Osteoporosis: Prolonged use may weaken bones; monitor bone density.
• Mental health: You might have mood swings, anxiety, or depression.
• Checking for infection: Be on the lookout for signs of infection while you’re getting treatment.
• Checking blood sugar levels: People with diabetes need to check their blood sugar levels very often.
• Slowly lowering the dose: To avoid adrenal insufficiency, you should talk with a doctor to slowly lower the dose.

Conclusion

Omnacortil 40 mg Tablet is a good medicine for treating many autoimmune and inflammatory diseases. It is a useful tool in clinical practice because it has strong anti-inflammatory and immunosuppressive effects. But it’s important to take this medicine only under the supervision of a doctor or other healthcare professional to reduce the risk of side effects and drug interactions.

References

https://www.ncbi.nlm.nih.gov/books/NBK534809/

https://pubchem.ncbi.nlm.nih.gov/compound/Prednisolone

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