Orgie 20 Mg Oral Strips

Orgie 20 mg Oral strips is a medication containing Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction (ED) and Benign prostatic hyperplasia. It works by works by increasing blood flow to the penis, relaxing the muscles in the penile blood vessels, and helping to achieve and maintain an erection.

 Key Features

How does Orgie 20 mg Oral strip work?

• Inhibition of PDE5 enzyme: This Phosphodiesterase Type-5 enzyme enhances cyclic guanosine monophosphate (cGMP) levels by causing dilation of blood vessels in the penis.
• Increasing nitric oxide release: It leads to nitric oxide release, with sexual excitement, release of nitric oxide is intensified, leading to elevated levels of cGMP.
• Smooth muscle relaxation: Tadalafil reduces symptoms of BPH by enhancing urine flow in bladder and prostate gland.

Usage

• Treats ED and BPH symptoms.
• Take 1 tablet about 1 hour before sexual activity (20mg).
• Maximum frequency: 1 tablet in 24 hours.
• Can be taken with or without food.

Uses

• It is use to treat Erectile dysfunction.
• Benign Prostatic Hyperplasia, managing symptoms such as urgency to urinate, poor stream, and incontinence.

 Dosage

• Starting dose: 10mg.
• May be increased to 20mg or decreased to 5mg based on individual response.
• For BPH, the recommended dose is 5mg once daily.

Side effects

• Headache
• Flushing
• Poor nasal congestion
• Back pain
• Muscle aches
• Indigestion
• Diarrhea
• Priapism (prolonged erection)
• Sudden loss of vision or hearing
• Cardiovascular events, including heart attack and stroke

Interactions 

• CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): Increase Tadalafil levels, CYP3A4 inhibitors can retard the metabolism of Tadalafil, with consequent higher levels and a greater risk of adverse effects.
• CYP3A4 Inducers (e.g., rifampicin, bosentan): Reduce tadalafil concentration, CYP3A4 inducers may speed up Tadalafil metabolism, weakening is efficacy.
• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Severe hypotension, Tadalafil may enhance the blood pressure-lowering effects of nitrates and cause potentially hazardous reductions in blood pressure.
• Alpha-blockers (e.g., doxazosin, tamsulosin): Increase risk of hypotension, Tadalafil has the potential to increase alpha-blockers hypotensive effects.

Pharmacokinetics

Pharmacokinetic interactions are very important in anticipating and managing future drug interactions, allowing for safe and effective therapy.

• Rapid absorption, peak levels 2 hours.
• Half-life: 17.5 hours.
• Metabolized by CYP3A4.

Precautions 

• Notify your physician if you are with any prior history of heart diseases, including angina or heart failure.
• Tadalafil containing Orgie oral strips may reduce blood pressure, so be cautious if you are with hypotension.
• Dose reduction may be required if you suffer from severe kidney or liver impairment.
• Generally, tadalafil is a safe and well-tolerated drug for the treatment of ED and BPH when taken according to directions. Nevertheless, it’s important to adhere to your physician’s recommendations and consult your doctor about any possible risks or interaction with other drugs.

 Conclusion

Orgie 20 mg oral strips is an effective treatment for ED and BPH symptoms.

Tadalafil is a drug that is prescribed for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It works by inhibiting the action of phosphodiesterase type 5 (PDE5), which results in elevated levels of cyclic guanosine monophosphate (cGMP) and enhanced blood flow. Follow prescribed dosage and precautions for safe use. Consult a doctor for personalized advice.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Tadalafil-d3

https://www.ncbi.nlm.nih.gov/books/NBK603743/

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