Orgie Plus Oral Strips

Orgie Plus Oral Strips combine Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, and Dapoxetine, a selective serotonin reuptake inhibitor (SSRI). This combination treats erectile dysfunction (ED) and premature ejaculation (PE).

These active ingredient, Tadalafil 20 mg, A PDE5 inhibitor that relaxes smooth muscles, increasing blood flow to the penis, facilitating erection. Whereas Dapoxetine 10 mg: An SSRI that delays ejaculation, improving control and treating PE.

Key Features

How does Orgie Plus Oral Strips work?

1. Tadalafil

• Inhibits PDE5, increasing the levels of intracellular cGMP.
• cGMP relaxes smooth muscles, increasing blood flow to the penis.
• It facilitates erection and improves erectile function.

2. Dapoxetine

• Raises serotonin levels, thus delaying ejaculation.
• Enhances control and treats PE.

Usage

• Treats Erectile dysfunction and Premature Ejaculation in adult males.
• Take one strip orally, as directed, 30 minutes to 1 hour before sexual activity.

Dosage

One strip (Tadalafil 20 mg + Dapoxetine 10 mg) as needed, not exceeding one strip per day.

Side effects

• Headache
• Dizziness
• Nausea
• Diarrhea
• Flushing
• Back pain
• Muscle aches
• Priapism, or prolonged erection
• Serotonin syndrome (rare)
• Seizures, rare
• Loss of vision or hearing rarely

Interaction

• Nitrates: Contraindicated because of the risk of severe hypotension.
• Alpha-blockers: May increase risk of hypotension.
• Antihypertensives: May increase risk of hypotension.
• SSRIs, SNRIs: Potential risk of serotonin syndrome
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): May increase Tadalafil levels.

Pharmacokinetics

1. Tadalafil:

• Rapid absorption, peak levels 2 hours.
• Half-life: 17.5 hours.
• Metabolized by CYP3A4.

2. Dapoxetine:

• Rapid absorption, peak levels 1-2 hours.
• Half-life: 1-2 hours.
• Metabolized by CYP2D6 and CYP3A4.

Efficacy

• A randomized, double-blind study published in the journal International Urology and Nephrology established that Tadalafil 5 mg ODF was comparable in efficacy to Tadalafil 5 mg tablets in improving erectile function in men with mild-to-moderate erectile dysfunction.
• Another study regarding combination therapy of Dapoxetine and Tadalafil showed significant improvement in erectile function and symptoms of premature ejaculation.

Safety

• The side effects reported in the studies were minimal, including headache, gastrointestinal upset, and muscle pain.
• The ODF formulation had a superior safety profile compared to the tablet formulation.

Important Consideration

• Orgie Plus oral strips are highly potent in treating erectile dysfunction and premature ejaculation.
• The combination of Tadalafil and Dapoxetine is generally well-tolerated, with few side effects. ODF formulation provides a convenient and safe mode of treatment.
• Results will, of course, vary from person to person, and one should always consult a healthcare professional before beginning any type of new medication.

Precautions

• Contraindicated: Patients with cardiovascular disease, hypotension, or taking nitrates.
• Caution: Patients with bleeding disorders or those on anticoagulants.
• Severe renal or hepatic impairment in patients. Patients with a history of priapism or Peyronie’s disease.

Conclusion

 Orgie Plus Oral Strips with Tadalafil 20 mg and Dapoxetine 10 mg effectively treat erectile dysfunction and premature ejaculation by inhibiting PDE5, increasing the levels of intracellular cGMP, and dapoxetine raise the serotonin levels, thus delaying ejaculation. However, use with caution and under medical supervision due to potential interactions and side effects. Consult a healthcare professional before use, especially if you have underlying medical conditions or take other medications.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC10929668/

https://pubmed.ncbi.nlm.nih.gov/16307008/

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