Priligy 30mg

Priligy is a medicinal drug designed to treat premature ejaculation (PE) in men using the active substance Dapoxetine Hydrochloride, a selective serotonin reuptake inhibitor (SSRI). It works by modulating serotonin levels in the nervous system, helping men delay ejaculation and improve control during sexual activity.

Key Features 

How does Priligy 30 mg work?

• Dapoxetine works by raising the level of serotonin in the brain, which in turn is said to delay ejaculation.

• It selectively inhibits serotonin reuptake, increasing serotonin concentration in the synaptic cleft, thereby enhancing serotonin’s action on post-synaptic receptors.

Uses

Priligy 30 mg is taken by mouth, as needed, 1-3 hours before sexual activity.

Maximum dosage is Priligy 60 mg/day.

Dosage

• Initial dose: 30 mg
• Maximum dose: 60 mg (if 30 mg is ineffective and well-tolerated)

Side Effects

• Nausea
• Dizziness
• Headache
• Diarrhea
• Insomnia
• Serotonin syndrome
• Seizures (rare)

Interaction

• Drug Interaction
• Food Interaction
• Disease Interaction

Drug Interaction

• Monoamine Oxidase Inhibitors (MAOIs): Contraindicated due to risk of serotonin syndrome. Examples include phenelzine and tranylcypromine. If MAOIs are stopped, there must be a 14-day washout before starting Priligy.

• Other SSRIs/SNRIs: Concomitant use is contraindicated because of increased risk of serotonin syndrome. Examples include fluoxetine, paroxetine, venlafaxine.

• CYP3A4 Inhibitors: May significantly increase dapoxetine levels, such as ketoconazole, itraconazole, ritonavir, and clarithromycin.

• CYP2D6 Inhibitors: Can increase levels of dapoxetine: e.g., fluoxetine, paroxetine, quinidine.

• Phosphodiesterase-5 inhibitors: May be used concomitantly with caution in individuals with ED and PE: e.g., sildenafil, tadalafil.

• Medications affecting bleeding: May increase bleeding risk when combined with anticoagulants or NSAIDs; examples include warfarin, aspirin, and ibuprofen.

• Lithium and Tryptophan: May increase risk of serotonin syndrome.

Food Interaction

• Alcohol: May increase the risk for adverse reactions including dizziness, somnolence, and altered judgment. May also contribute to the risk of syncope.

• Grapefruit juice: May increase levels of dapoxetine by inhibiting CYP3A4 metabolism.

Disease Interactions

• Cardiovascular Conditions: Priligy should be used cautiously in patients with heart failure, significant cardiac disease, or a history of syncope due to the risk of orthostatic hypotension.

• Psychiatric Disorders: Priligy is contraindicated in patients with a history of mania, severe depression, bipolar disorder, or schizophrenia since it may aggravate these disorders.

• Hepatic impairment: Priligy is contraindicated in patients with moderate to severe hepatic impairment because it is extensively metabolized via the liver.

• Renal Impairment: Priligy should be used cautiously in patients with severe renal impairment, and medical guidance may be required.

• Epilepsy and Seizure Disorders: Priligy should be used cautiously in patients with history of seizures, as SSRIs may lower seizure threshold.

Pharmacokinetics

• Absorption: Rapid; peak levels occur within 1-2 hours.
• Metabolism: Hepatic, via CYP2D6 and CYP3A4.
• Elimination: Renal, with a half-life of 1-2 hours.

Precautions

• Priligy should be used with caution in patients with cardiovascular disorders and in particular those with risk of orthostatic hypotension.

• Priligy is contraindicated in patients taking MAOIs or other serotonergic medications.

• Patients with a history of psychiatric disorders should be closely monitored for mood changes or suicidal ideation.

• Should be used with caution in patients with bleeding disorders or on anticoagulants.

• Patients should be instructed to avoid alcohol consumption while taking Priligy.

Conclusion

Priligy is a medically tested drug for treating premature ejaculation with demonstrated efficacy and safety under proper medical guidance. As an SSRI developed for on-demand use, it offers a focused approach to PE management. Consultation with a doctor before its intake helps evaluate one’s suitability, absence of contraindications, and achievement of maximum benefit with minimal risks. Follow-up on a regular basis with healthcare providers is required so that modifications are carried out according to effectiveness.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3441133/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3273363/

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