Key Features

Different doses of Silditop

Features of Medication

• Medications like Silditop 50 mg, Silditop 100 mg contains Sildenafil Citrate as an active ingredient.
• These medications are being used to treat erectile dysfunction (ED).
• These medications have similar mechanism of action.
• These typically takes 30-60 minutes after oral administration. 

How does it work?

Silditop smooths out blood vessels since Sildenafil Citrate blocks the phosphodiesterase type 5 enzyme that controls the blood flow. It increases blood flow to the penis, allowing for a natural reaction to sexual stimulation and causing men to be able to get and sustain erections.

• PDE5 inhibition: Silditop includes Sildenafil Citrate, which selectively inhibits phosphodiesterase type 5 (PDE5) enzyme.
• Increased cGMP levels: PDE5 inhibition results in elevated levels of cyclic guanosine monophosphate (cGMP) in the penis.
• Smooth muscle relaxation: cGMP induces smooth muscle relaxation, enabling the blood vessels to dilate.
• Increased blood flow: Vascular dilation increases blood flow to the penis, facilitating an erection.

Inhibition of PDE5 enzyme

Dosage

• Generally recommended dose is 50 mg, taken approximately 1 hour before sexual activity.
• Dose can be adjusted to 25 mg or 100 mg based on individual response and tolerance.

Benefit of using Silditop

• Silditop is to be taken for the treatment of Erectile dysfunction.
• Enhances erectile function, enabling men to achieve and maintain an erection.
• Can improve sexual confidence and overall quality of life. 

Pharmacokinetics

• Absorption: Sildenafil Citrate is absorbed rapidly, with the maximum plasma concentrations attained within 60 mins.
• Distribution: It is widely distributed, approximately 105 L.
• Metabolism: It is metabolized in liver by CYP3A4, with a half-life of approximately 4 hours
• Excretion: The metabolites are excreted through feces (80%) and urine (13%).

Silditop interactions are classified into several categories:

• Drug interactions
• Food interactions
• Disease interactions 

Drug Interaction

• Nitrates: Contradicted because of the potential for severe hypotension (e.g., nitroglycerin, isosorbide dinitrate)
• Alpha-blockers: Can cause symptomatic hypotension (e.g., doxazosin, terazosin)
• Antihypertensives: Can increase the hypotensive effects (e.g., beta-blockers, calcium channel blockers)
• Protease inhibitors: Can raise sildenafil levels (e.g., ritonavir, saquinavir)
• Antibiotics: Can raise sildenafil levels (e.g., erythromycin, clarithromycin)

Food Interaction

• Grapefruit juice: Can raise sildenafil levels
• Alcohol: Can enhance the chances of side effects such as dizziness and hypotension

Disease Interactions

• Cardiovascular Conditions: Patients with advanced heart disease, recent myocardial infarction, or uncontrolled hypertension must get in touch with their physician prior to using Silditop.
• Hepatic Impairment: Patients with liver failure might need dosage adjustment, as Silditop is metabolized through the liver.
• Renal Impairment: Patients with kidney dysfunction can also need dose adjustments since Silditop is eliminated by the kidneys.

Other Interactions

• Other ED medications: Must not be used with Silditop without the advice of a healthcare provider
• Certain medical conditions: Patients with heart disease, high blood pressure, or other disorders must consult a healthcare provider before using Silditop. 

Pharmacokinetics

• Absorption: Sildenafil Citrate is absorbed quickly, with the maximum plasma concentrations attained within 30-120 minutes.
• Metabolism: Silditop is metabolized in the liver and has a half-life of about 3-4 hours.
• Excretion: The metabolites are excreted through feces and urine.

Side effects

• Headache
• Flushing
• Nasal Congestion
• Indigestion
• Dizziness  

Precautions

• Silditop is to be administered cautiously in patients with cardiovascular conditions.
• Silditop is not to be administered to patients consuming nitrates.
• Patients with risk factors for priapism are to be administered Silditop cautiously.
• Usually administered an hour prior to expected sexual activity, with a maximum rate of once daily.
• Use is contraindicated in women, children, and adolescents because of the lack of research.

Conclusion

Silditop is a medically tested medication to treat erectile dysfunction and pulmonary arterial hypertension with efficacy and safety under medical guidance. It is necessary to consult a doctor prior to taking the medicine in order to get the best results with minimal risks.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Sildenafil-Citrate

https://pubmed.ncbi.nlm.nih.gov/10400408/

https://pubmed.ncbi.nlm.nih.gov/18516312/