Key Features

About
Drug Class	Phosphodiesterase Type 5
Components	Sildenafil Citrate
Uses	Erectile Dysfunction

Different doses of Stallegra

• Stallegra 100 mg
•  Stallegra 150 mg
•  Stallegra 200 mg

Medication	Active ingredients	Dosage	Duration of Action	Uses
Stallegra 100 mg	Sildenafil Citrate	100 mg	Almost up to 4–6 hours	ED Treatment
Stallegra 150 mg	Sildenafil Citrate	150 mg	Almost up to 4–6 hours	ED Treatment
Stallegra 200 mg	Sildenafil Citrate	200 mg	Almost up to 6 hours	ED Treatment

Features of Medication

• Medications like Stallegra 100 mg, Stallegra 150 mg, and Stallegra 200mg contain Sildenafil Citrate as an active ingredient.
• These medications are being used to treat erectile dysfunction (ED).
• These medications have similar mechanism of action.
• These typically takes 30-60 minutes after oral administration.

How does it work?

Stallegra relaxes blood vessels as Sildenafil Citrate inhibits the phosphodiesterase type 5 enzyme that regulates blood circulation. It enhances blood flow to the penile region, enabling a natural response to sexual arousal and helping men achieve and maintain firm erections.

• PDE5 inhibition: Stallegra contains Sildenafil Citrate, which selectively blocks the phosphodiesterase type 5 (PDE5) enzyme.
• Increased cGMP levels: Inhibiting PDE5 leads to elevated levels of cyclic guanosine monophosphate (cGMP) in the penile tissue.
• Smooth muscle relaxation: Elevated cGMP causes smooth muscle relaxation, allowing the blood vessels to expand.
• Enhanced blood flow: Expansion of blood vessels increases blood flow to the penis, supporting erectile function.

Dosage 

• Stallegra is available in three dosage strengths: 100 mg, 150 mg, and 200 mg tablets.
• The typical starting dose is 100 mg, to be consumed about one hour prior to engaging in sexual activity.
• Depending on effectiveness and tolerability, the dosage may be increased to 150 mg or 200 mg as needed.

Benefit of using Stallegra 

• Effectively treats erectile dysfunction by improving the ability to achieve firm erections.
• Helps men sustain erections long enough for satisfactory sexual intercourse.
• Boosts sexual performance and self-assurance, contributing to enhanced intimate relationships and overall well-being.

Pharmacokinetics 

• Absorption: Sildenafil Citrate gets absorbed quickly into the bloodstream, reaching peak plasma levels approximately 30 to 120 minutes after oral administration.
• Distribution: The drug distributes throughout body tissues with a volume of distribution around 105 L.
• Metabolism: Hepatic metabolism occurs primarily through the CYP3A4 enzyme pathway, with an elimination half-life of roughly 3 to 5 hours.
• Excretion: Metabolized compounds are eliminated mainly via feces (approximately 80%) and to a lesser extent through urine (about 13%).

Stallegra interactions are classified into several categories:

• Drug interactions
• Food interactions
• Disease interactions

Drug Interaction

• Nitrates: Contraindicated due to risk of severe drop in blood pressure (e.g., nitroglycerin, isosorbide mononitrate)
• Alpha-blockers: May lead to symptomatic low blood pressure (e.g., tamsulosin, alfuzosin)
• Antihypertensive medications: May potentiate blood pressure-lowering effects (e.g., ACE inhibitors, diuretics)
• Protease inhibitors: May elevate sildenafil concentrations in blood (e.g., indinavir, nelfinavir)
• Certain antibiotics: May increase sildenafil plasma levels (e.g., azithromycin, telithromycin)

Food Interaction

• Grapefruit juice: May increase sildenafil concentration in the body
• Alcoholic beverages: May heighten risk of adverse effects including lightheadedness and low blood pressure

Disease Interactions

• Cardiovascular Conditions: Individuals with severe cardiac disorders, recent heart attack, or poorly controlled high blood pressure should consult their doctor before taking Stallegra.
• Hepatic Impairment: Those with compromised liver function may require modified dosing, as Stallegra undergoes hepatic metabolism.
• Renal Impairment: Individuals with reduced kidney function may also require dose modifications due to renal elimination pathways.

Other Interactions

• Other ED medications: Should not be combined with Stallegra unless prescribed by a healthcare professional
• Certain medical conditions: Individuals with cardiac problems, elevated blood pressure, or other health concerns should seek medical advice before initiating Stallegra.

Pharmacokinetics

• Absorption: Sildenafil Citrate is rapidly absorbed following oral administration, with peak plasma levels reached within 30-120 minutes.
• Metabolism: Stallegra undergoes hepatic biotransformation with an elimination half-life ranging from 3-4 hours.
• Excretion: Metabolic byproducts are eliminated primarily through fecal and urinary routes.

Side effects

• Headache
• Facial flushing
• Stuffy nose
• Upset stomach
• Lightheadedness

Precautions

• Stallegra should be used with caution in individuals with heart-related conditions.
• Stallegra must not be given to individuals taking nitrate medications.
• Individuals at risk for prolonged erection (priapism) should use Stallegra with caution. Typically taken one hour before anticipated sexual activity, not exceeding once per day.
• Not recommended for use in women, children, and adolescents due to insufficient clinical data.

Conclusion

Stallegra is a clinically proven treatment for erectile dysfunction that demonstrates both effectiveness and safety when used under proper medical supervision. It is essential to seek consultation with a healthcare provider before starting this medication to ensure optimal therapeutic outcomes while minimizing potential health risks.

References:

• https://www.ncbi.nlm.nih.gov/books/NBK558978/
• https://doi.org/10.1016/B978-008055232-3.62619-4