Vidalista is a medication used to treat erectile dysfunction (ED) and contains the active ingredient Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the smooth muscles in the penis, increasing blood flow, and helping men achieve and maintain an erection.

Key features 

Vidalista Medication different dosage

• Super Vidalista 80 mg
  
  
• Vidalista 2.5 mg
  
  
• Vidalista 5 mg
  
  
• Vidalista 10 mg
  
  
• Vidalista 20 mg
  
  
• Vidalista 40 mg
  
  
• Vidalista 60 mg
  
  
• Vidalista black 80 mg
  
  
• Vidalista CT 20 mg
  
  
• Vidalista professional 20 mg
  
  

Dosage

Doses of Vidalista is based on the condition and individual requirements:

• For Erectile Dysfunction (ED) purpose, initial dose is usually 2.5 mg daily or as needed 40 mg, taken prior to sexual intercourse.
  
  
• For Benign Prostatic Hyperplasia (BPH), 5 mg daily
  
  
• For PAH (Pulmonary Arterial Hypertension), Dosage may vary from individual to individual, consult a doctor.

Applications of Tadalafil

Vidalista is most commonly prescribed for:

• Erectile Dysfunction: Managing ED in men, facilitating achieving and sustaining erections.
  
  
• Benign Prostatic Hyperplasia: Managing symptoms such as urgency to urinate, poor stream, and incontinence.
  
  
• Pulmonary Arterial Hypertension: Decreasing pulmonary blood vessel pressure, enhancing exercise capacity.

 
Benefits of using Vidalista medication

• Long duration of action up to 36 hours, enabling more spontaneity.
  
  
• Enhanced erectile function, more confidence, and satisfaction.
  
  
• Enhanced urine flow and lessened symptoms for Benign Prostatic Hyperplasia.
  
  

How Does Vidalista Work?

Vidalista functions by inhibiting the phosphodiesterase type 5 (PDE5) enzyme that breaks down cyclic guanosine monophosphate (cGMP). cGMP is a molecule that causes the smooth muscles in the penis to relax, which leads to more blood flow and results in a strong and long-lasting erection. With the inhibition of PDE5, Vidalista raises the levels of cGMP, which helps men with ED to get and sustain an erection.

Common side effects of Vidalista are:

• Headache
  
  
• Dizziness
  
  
• Flushing
  
  
• Nasal congestion
  
  
• Back pain
  
  
• Muscle pain
  
  
• Indigestion

Severe side effects can occur, including:

• Priapism (prolonged erection)
  
  
• Sudden vision loss
  
  
• Sudden hearing loss
  
  
• Heart problems

 
Interactions

Tadalafil interactions are classified into several categories:

1. Drug interactions
   
   
2. Food interactions
   
   
3. Disease interactions

Drug Interactions:

• CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): Increase Tadalafil levels, CYP3A4 inhibitors can retard the metabolism of Tadalafil, with consequent higher levels and a greater risk of adverse effects.
  
  
• CYP3A4 Inducers (e.g., rifampicin, bosentan): Reduce tadalafil concentration, CYP3A4 inducers may speed up Tadalafil metabolism, weakening is efficacy.
  
  
• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Severe hypotension, Tadalafil may enhance the blood pressure-lowering effects of nitrates and cause potentially hazardous reductions in blood pressure.
  
  
• Alpha-blockers (e.g., doxazosin, tamsulosin): Increase risk of hypotension, Tadalafil has the potential to increase alpha-blockers hypotensive effects.
  
  
• Antihypertensives: (e.g., ACE inhibitors, beta-blockers): Additive hypotensive effects, Tadalafil has the potential to enhance the blood pressure-reducing effects of these medications, so the risk of hypotension is increased.
  
  
• Alcohol: Increased the risk of hypotension and side effects: Alcohol can potentiate the blood pressure-lowering action of Tadalafil and enhance the risk of side effects such as dizziness and headache.
  
  
• Other PDE5 Inhibitors: Increased risk of side effects, Concomitant use of Tadalafil with other PDE5 (e.g., Sildenafil, Vardenafil) may raise the risk of side effects because of additive effects.

Therapeutic Suggestions

• Adjustments in dose can be made when Tadalafil is administered with CYP3A4 inhibitors or inducers.
  
  
• Concomitant use should be avoided of Tadalafil with nitrates or other PDE5 inhibitors.
  
  
• Blood pressure should be monitored when Tadalafil is administered with antihypertensives or alpha-blockers.
  
  
• Alcohol should be consumed in limited amounts to prevent side effects.

 
Pharmacokinetics

Pharmacokinetic Interaction takes place when a drug influences the Absorption, Distribution, Metabolism, or excretion (ADME) of another drug. This may result in an alteration in the concentration of one or both drugs in the body and thus may alter their effects or enhance the risk of side effects.

There are various categories of Pharmacokinetic interactions:

• Absorption interaction
  
  
• Distribution interaction
  
  
• Metabolism interaction
  
  
• Erection Interaction
  
  

Pharmacokinetic interactions are very important in anticipating and managing future drug interactions, allowing for safe and effective therapy.

Does Vidalista have any pharmacokinetic interaction?

Yes, Vidalista also has a number of pharmacokinetic interactions. It can be metabolized by cytochrome P450 (CYP) 3A4, and as bosentan induces CYP2C9 and CYP3A4, a pharmacokinetic interaction is possible between these agents.

Food Interactions

•  Grapefruit: Grapefruit and grapefruit juice may raise levels of tadalafil in the blood, which could result in higher side effects.
  
  
• Alcohol: Drinking a lot of alcohol with tadalafil might cause side effects to be greater, such as dizziness, headache, and low blood pressure. Taking moderate alcohol is recommended.
  
  

Disease Interactions

• People with heart disease or high blood pressure might have increased risks when using tadalafil.
  
  
• Abnormal liver or kidney function may change the metabolism and elimination of tadalafil, requiring dose modification.
  
  
• Diseases such as retinitis pigmentosa might be worsened by tadalafil.
  
  
• Priapism, a lasting erection of the penis, may occur with tadalafil in some patients.
  
  

Contraindications of Tadalafil

 Tadalafil, a drug employed to cure erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), has specific contraindications:

1. Nitrates

• Tadalafil must not be used with nitrates, for it results in a remarkable fall in blood pressure.
  
  
• Nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
  
  

2. Guanylate Cyclase Stimulators

• Tadalafil is not recommended to be used with guanylate cyclase stimulators like riociguat since it can also lead to a sudden drop in blood pressure.
  
  

3. Hypersensitivity

• If you are hypersensitive or allergic to tadalafil or any component of the drug, you should avoid taking it.
  
  

4. Severe Health Conditions

• Some heart conditions, e.g., severe heart failure or uncontrolled hypertension, might necessitate caution or contraindication.
  
  
• Severe liver or kidney dysfunction can necessitate dose modification or contraindication.
  
  

5. Other Considerations

• Elderly or patients with specific health conditions might need dose adjustment or more intensive monitoring.
  
  
• Tadalafil may interact with other drugs, so it’s important to tell your physician all the medications you’re taking. 
  
  

Reducing Interactions

•  Discuss medication lists with healthcare professionals on a regular basis
  
  
• Follow dosage directions.
  
  
• Reduce alcohol intake.
  
  
• Avoid grapefruit and grapefruit juice.
  
  
• Inform medical professionals regarding any health conditions or medication being used.
  
  

Precautions

• Vidalista should be used cautiously in patients with cardiovascular disease.
  
  
• Vidalista should be used cautiously in patients with severe hepatic impairment.
  
  
• Vidalista should be used cautiously in patients with severe renal impairment.

Conclusion

Vidalista is a potent drug for the treatment of ED with an action time of as long as 36 hours. Although generally well tolerated, Vidalista can produce side effects and interact with some drugs. Patients need to discuss with their doctor prior to taking Vidalista, particularly if they have any pre-existing medical conditions or are on other drugs.

References

 https://pubchem.ncbi.nlm.nih.gov/compound/Tadalafil-d3

https://www.ncbi.nlm.nih.gov/books/NBK603743/

 FAQs

1) How long does it take for Vidalista to work?

Vidalista generally becomes effective between 30 minutes to 1 hour after intake.

2) Can I use Vidalista with food?

Vidalista may be used with or without food.

3) Is Vidalista suitable for everyone?

Vidalista is not suitable for everyone, especially those with some medical conditions or using some medicines.

4) Can Vidalista be used with other medicines?

Vidalista can interact with some medicines, so it’s necessary to consult your doctor before taking it with other medicines.