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What is ED?

Erectile dysfunction is the persistent inability to achieve or maintain an erection sufficient to permit satisfactory sexual performance. An erection requires a smooth muscle relaxation cascade triggered by nitric oxide, raising cyclic GMP, which lets blood flood the corpora cavernosa. Vascular blockage, nerve damage, hormonal imbalance, or psychological stress may interrupt this pathway leading to Erectile Dysfunction.

It’s not just a normal part of aging, though prevalence does rise with age. Affects approx. 30 % of men aged 40-70, and up to 70 % > 70.

What leads to Erectile issue in men?

Causes

  • Vascular: Atherosclerosis, Hypertension, Diabetes, Smoking
  • Neurogenic: Spinal Injury, Multiple Sclerosis, Pelvic surgery, Peripheral neuropathy
  • Hormonal: Low testosterone, Hyperprolactinemia, Thyroid disease
  • Medication induced: Beta-blockers, thiazides, antidepressants, anti-psychotics, 5-alpha reductase inhibitor
  • Psychogenic: Anxiety, Depression, Performance stress, Relationship issues.

  • Mixed: Combination of organic and Psychogenic factors.

Treatment

  • PDE5 Inhibitor Medications: Sildenafil, Tadalafil, Vardenafil, and Avanafil.
  • Topical anesthetics: Lidocaine -prilocaine cream or spray to reduce glance sensitivity.
  • SSRIs, Selective serotonin reuptake inhibitors: Paroxetine, Sertraline e.g., Dapoxetine
  • Intra-uretheral suppositories: Alprostadil
  • Surgical implants: Penile Dorsal-nerve neurolysis
  • Psychosexual therapy: Cognitive behavioural therapy, Sex therapy

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What is PE?

Premature ejaculation (PE) is one of the most prevalent sexual disorders that afflict countless men across the globe. Premature ejaculation is a condition in which a man ejaculates earlier during sexual intercourse than he or his partner desires. Premature ejaculation can be divided into two forms: lifelong (primary) and acquired (secondary). Lifelong PE is when the man has constantly had PE, whereas acquired PE occurs after some period of normal sexual functioning. 

What leads to Premature ejaculation in Mens

Causes

  • Biological: Hypersensitivity, Serotonin Imbalance, Thyroid problems, and inflammation (Prostatitis).
  • Psychological: Anxiety, Stress, Depression, Performance Pressure.
  • Behavioural: Infrequent Sex, Learned Pattern, Lack of awareness.
  • Medical: Erectile Dysfunction, Certain medications, SSRIs

Affects approximately 20‑30 % of men at any time in their lives.

5‑10 % experience lifelong, that is, primary Premature Ejaculation the rest are acquired or situational.

SSRIs (Selective serotonin reuptake inhibitors), have effects on ejaculation because they increase serotonin levels within the brain. Daily or on-demand SSRIs that is paroxetine, sertraline, dapoxetine are frequently used to delay ejaculation and for treating premature ejaculation.

Treatment

  • Medications: Priligy 30 mg,Dapoforce 30 mg, Vidalista 80 mg, Poxet 60 mg, Super Krrista.
  • Daily SSRIs, Selective serotonin reuptake inhibitors that increase serotonin and leads to delay ejaculation.
  • PDE-5 Inhibitor: Useful when Premature ejaculation co-exists along with erectile dysfunction.
  • Psychosexual therapy: Cognitive-behavioural therapy, couples’ therapy, or sex therapy focused on anxiety and relationship dynamics.

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