These skin related issues can be caused by:

• Excess sebum
• Follicular hyperkeratinisation
• Acne bacteria
• Inflammation

The factors that may triggers the skin conditions

• Hormonal factor
• Genetics
• Diet
• Stress
• Medications like steroids
• Occlusion
• Smoking

These factors may trigger the skin conditions.

Tretinoin is a vitamin A derivative that works at the DNA level to normalize skin cell behaviour. It is prescribed retinoid that may deals with acne and anti-aging by binding nuclear receptors to change gene expression. This is best for acne prone skin and photo aging because it prevents comedones, speeds cell turnover and also builds collagen.

Tretinoin Formulation for dealing with Acne and Antiaging:

• Tretinoin 0.05% RX Cream
• Tretin 0.025% Cream
• Revize Micro 0.04% Gel
• Supatret 0.1% Gel
• Trebor Cream
• Tronin MS gel
• Trunex MS gel
• MyTret Gel
• Tretiheal 0.025% Cream 

How does Tretinoin work?

• It may enter keratinocytes as tretinoin is lipophilic, passes cell membrane easily.
• In the nucleus it may binds RAR-alpha, RAR-beta, and RAR-gamma nuclear receptors.
• This turn genes on off, this may regulate more than 500 genes control cell growth, differentiation, collagen, inflammation.
• This tends sticky tight dead cells shed normally just by preventing microcomedones speeds turnover from 28 days to 14 days, followed by anti-inflammation. 

Safety & Efficacy

• According to safety concern it may show some side effects like irritation, purging, photosensitivity, initial dryness, swelling, allergic reaction, headache, fever, fatigue, weakness, bone pain, nausea and vomiting.
• Tretinoin can be used in dealing with Acne prone skin, acne vulgaris, wrinkles and other skin related issues. 

Precautions

• Pregnant women should avoid taking such products.
• Avoid it with other retinoids or Vitamin A supplements as it may increase the risk of hypervitaminosis A toxicity.
• It may interact adversely with Tetracyclines, intracranial pressure risk.