Asthalin 4 mg tablet is a pharmaceutical bronchodilator tablet that is used in treating asthma and COPD condition. It is formulation of salbutamol sulphate. It may work by binding to beta-2 receptors or bronchial smooth muscle cells and relaxing the smooth muscle by activating Protein kinase A by increasing cAMP level.
Key Features
| About Asthalin 4 mg Tablet | |
|---|---|
| Drug Class | Bronchodilator, asthmatic |
| Subclass | Beta-2 Adrenergic Agonist |
| Asthalin 4 mg Tablet – Product Details | |
|---|---|
| Composition | Active Ingredient:
Inactive Ingredients:
|
| Packaging Type | Blister |
| Pack Size | 20 × 3 × 30 |
| Dosage | 1 tablet 3–4 times a day |
| Therapeutic Class | Anti-asthamatic |
| Action Class | Short-Acting Beta2-Agonist (SABA) |
| Chemical Class | Phenylethanolamine Derivative |
| Manufacturer | Cipla |
| Shelf Life | 24–36 Months |
| Uses | Treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD) Symptom. |
| Country of Origin | India |
| Storage | Store below 30°C in a cool and dry place, protected from direct sunlight, moisture, and heat. |
How does Asthalin 4 mg Tablet may work?
Salbutamol is a selective beta-2 adrenoceptor agonist that may works by:
- It may work by binding to beta-2 receptors on bronchial smooth muscle cells, Gs protein may get activated this lead to increase in the level of adenyl cyclase and also may increase cyclic AMP.
- There’s increase in the level of CAMP this may activates protein kinase A, this phosphorylates myosin light chain kinase resulting in decrease in intracellular Ca2+ this may help in relaxing smooth muscle.
Side effects
- Fine tremor hands
- Nervousness
- Headache
- Tachycardia
- Palpitations
- Muscle cramps
- Insomnia
- Nausea
- Throat irritation
- Dizziness
Usage
- It can be used in the condition of bronchial asthma.
- It is also used in treating Chronic Obstructive Pulmonary Disease.
Dosage
- It can be taken (2-4 mg) 3-4 times a day.
- It can be taken after food to reduce gastric upset. It can be swallowed whole with water, do not crush SR tablets if they exist.
Interaction
- The non-selective beta-blockers interacts adversely by resulting it into severe bronchospasm, blocks salbutamol.
- Diuretics may increase the risk of hypokalaemia.
- Corticosteroids also may lead to hypokalaemia risk.
- MAO inhibitors and TCAs may increase the CV effects and increases the risk of hypertension.
Pharmacokinetics
- It gets rapidly absorbed from GI tract and also reaches Tmax at just 2-3 hours.
- The onset of action is almost 30 min oral vs 5 min inhaled, duration is almost 4-6 hours oral.
- It may follow hepatic metabolism via sulfotransferase to inactive salbutamol 4’O sulphate, here no CYP450 involved.
- Its half-life is almost about 3.8-6 hrs.
- It can be excreted up-to 64-98% urine as unchanged drug and metabolite, and 10% through feces.
Precautions
- It may lead to cardiovascular disease, CAD arrhythmia, severe hypertension, CHF can cause angina, arrhythmia.
- It may increase the chances of hyperthyroidism.
- In the case of diabetes, it worsens by causing Hyperglycemia, ketoacidosis.
- It can be avoided during pregnancy and Lactation.
- The one with hypersensitive to salbutamol should avoid taking such medications.
Conclusion
Asthalin 4 mg tablet is the best and effective pharmaceutical bronchodilator tablet that is used in treating asthma and COPD condition. It is formulation of salbutamol sulphate. It may work by binding to beta-2 receptors or bronchial smooth muscle cells and relaxing the smooth muscle by activating Protein kinase A by increasing cAMP level. This medication may show some side effects that vary from individual to individual, so need to consult your healthcare provider prior using any such medications.
Addy –
it is nice product