Danogen 200 Mg

Danazol containing Danogen 200 mg is derived from ethisterone which is synthetic androgen, it can be used in treating endometriosis, fibrocystic breast disease, and hereditary angioedema. It may work by suppressing pituitary gonadotropins i.e., it reduces FSH and LH release from the pituitary followed by inhibiting ovarian steroidogenesis, creating a hypoestrogenic state. It binds to androgen, progesterone, and glucocorticoid receptors.

Key Features

How does Danogen 200 mg work?

• It may suppress pituitary gonadotropins just by reducing FSH and LH release from the pituitary. This may lower estrogen production in women.
• This may work by inhibiting ovarian steroidogenesis, creating a hypoestrogenic state.
• It may also bind to androgen, progesterone, and glucocorticoid receptors. It also displaces testosterone from sex hormone-binding globulin, increasing free testosterone.
• There is increase in C1 esterase inhibitor levels, for hereditary angioedema.

Usage

• It can be used in treating endometriosis.
• Fibrocystic breast disease can also be treated.
• Hereditary angioedema (HAE) can also be treated by the action of Danogen drug.

Dosage

• It can be taken with to reduce stomach upset.
• If missed, do not doubled the dosage.

Side effects

• Dizziness
• Headache
• Weight gain
• Fluid retention
• Swelling
• Acne
• Oily skin
• Hair loss on scalp
• Hot flushes
• Vaginal dryness
• Mood changes
• Irregular periods (Amenorrhea)

Interactions

• Danazol may interact with warfarin and may increase the bleeding risk.
• Danazol is CYP3A4 inhibitor it may interact with statins and also may increase the risk of myopathy, rhabdomyolysis with simvastatin, lovastatin.
• Increase in the level of Carbamazepine may increase the toxicity.
• It may increase the immunosuppressant levels and also may increase kidney toxicity.
• Insulin or Oral diabetes drugs may alter the glucose tolerance.
• Androgenic fluid retention may reduce effectiveness.
• Alcohol consumption is to be avoided while taking Danazol medications as it may lead to side effects like nausea, and shortness of breath.

Pharmacokinetics

• It is well absorbed orally and with food increases bioavailability.
• It may reach the peak plasma at just 2-8 hours.
• It may follow hepatic metabolism via CYP3A4 to ethisterone and other metabolites.
• Half-life is approx. 4-5 hours, but biological effect may last longer due to pituitary suppression.
• The excretion is mainly in the form of urine and feces.

Precautions

• Pregnant and breast-feeding women should avoid taking danazol medications.
• If you are with prior medical condition of undiagnosed vaginal bleeding, severe liver, kidney, or heart disease, porphyria should avoid taking danazol medications.
• Need to monitor liver function, lipid profile, and complete blood count every 3 months.
• For every 6 months check signs of Virilization and pelvic exam.

Conclusion

Danazol containing Danogen 200 mg is derived from ethisterone which is synthetic androgen, it can be used in treating endometriosis, fibrocystic breast disease, and hereditary angioedema. It may work by suppressing pituitary gonadotropins i.e., it reduces FSH and LH release from the pituitary followed by inhibiting ovarian steroidogenesis, creating a hypoestrogenic state. It binds to androgen, progesterone, and glucocorticoid receptors. It may show some side effects like weight gain, fluid retention, swelling, acne, oily skin and decreased breast size, this may vary from individual to individual and to avoid this consult your healthcare provider.

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