Depaxil CR 37.5 Tablet

Depaxil CR 37.5 Tablet is a formulation of Paroxetine (SSRI class) is used in dealing with premature ejaculation, and is also used in dealing with major depressive disorder. CR is a controlled release formulation of paroxetine which is an antidepressant in the SSRI class. It may work by increasing the serotonin in synapses which helps in maintaining ejaculatory control. The CR form can be used in smoother delivery and also may reduce GI side effects.

Key Features

How does Depaxil CR 37.5 mg work?

Medication containing Paroxetine is an SSRI, it may work by:

• The increase in serotonin in the synapses, serotonin may help in regulating ejaculatory control. As Ejaculation is partly controlled by serotonin in the brain and spinal cord. Higher the serotonin especially at 5-HT2C receptors, tends to delay the ejaculatory reflex. As higher the serotonin longer, the time to ejaculation for many men.
• CR formulation may give steadier blood levels and vs immediate release, so some doctors may prefer it for daily use.

In the case of Depression, it is linked to low levels of serotonin in the brain.

• Paroxetine may block the reuptake pump in nerve cells.
• Normally after serotonin is released, it gets pulled back into the cell.
• Paroxetine blocks that so more the serotonin stays in the space between nerve cells i.e., the synapse.

Dosage

• It can be taken once a day with food.
• Do not crush or chew CR tablets just swallow whole tablet in mouth.
• Stopping suddenly the dosage may can cause discontinuation symptoms.

Usage

• Premature Ejaculation
• Major Depressive Disorder
• Post-Traumatic Stress Disorder
• Premenstrual Dysphoric Disorder

Side effects

• Dizziness
• Tremor
• Blurred vision
• Nausea
• Headache
• Diarrhea
• Insomnia
• Sexual Dysfunction
• Decreased Libido
• Delayed orgasm

Interaction

• Paroxetine medications can be avoided with MAO inhibitors like Phenelzine, Tranylcypromine, linezolid and methylene blue.
• Pimozide and Thioridazine may increase the risk of QT prolongation.
• It may can also interact with other serotonergic drugs like Tramadol, triptans, St. John’s Wort, and other SSRIs and SNRIs.
• It may interact with Benzodiazepines, alcohol and may increase sedation.

Pharmacokinetics

• CR formulation may slow down the absorption, it may reach at peak plasma concentration in just 6-10 hours.
• It is metabolized in liver via CYP2D6.
• Half-life is about approx. 21 hours.
• If paroxetine formulation taken with food then it may reduce nausea.

Precautions

• If you are hypersensitive to paroxetine then it should be avoided.
• Avoid it in the condition of pregnancy and breastfeeding.
• In the condition of Bipolar disorder also it should be avoided.
• If you are with bleeding disorder then avoid taking any such medications.
• In the condition of Glaucoma also it should be avoided.

Conclusion

Depaxil CR 37.5 mg can be safe and effective in dealing with Premature mature ejaculation and also in dealing with depression. It may work by increasing the serotonin in synapses which helps in maintaining ejaculatory control. It may have some side effects like dizziness, tremor, blurred vision, nausea, headache, diarrhea, insomnia, sexual dysfunction, decreased Libido and delayed orgasm. This side effects may can vary from individual to individual. Prior taking any such medications always consult healthcare provider or doctor to avoid any interactions.

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