Rollosert 50 Tablet

Rollosert 50 tablets are formulated to support the treatment of conditions in which low or dysregulated serotonin activity may contribute to persistent low mood, unwanted thoughts, anxiety or panic symptoms. This antidepressant contains sertraline. Sertraline has also been studied for premature ejaculation, given that SSRIs frequently have a delayed-ejaculation effect. It belongs to the selective serotonin reuptake inhibitor (SSRI) group of medicines. Depending on the clinician’s assessment, sertraline may also be used for panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder and also to treat premature ejaculation.

Key Features

How does the Rollosert 50 Tablet work?

Sertraline works by reducing the reabsorption, or reuptake, of serotonin by nerve cells in the brain. This leaves more serotonin available between nerve cells, which may help support mood regulation and reduce symptoms linked with depression, OCD and certain anxiety disorders.

Serotonin is a chemical messenger involved in mood, emotional responses, sleep, appetite, and behavior. Rollosert 50 Tablet does not change these symptoms overnight so it is important to take it consistently as prescribed and attend follow-up appointments.

Usage

Rollosert 50 Tablet is commonly used for the following:

• Major depressive disorder
• Obsessive-compulsive disorder (OCD)
• Panic disorder, with or without agoraphobia
• Social anxiety disorder
• Post-traumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder, when considered appropriate by the prescriber 
• Premature ejaculation

A doctor may use Rollosert 50 Tablet for a condition not listed above when its expected benefit is clinically appropriate.

Dosage 

Take the Rollosert 50 Tablet exactly as advised by your doctor. It is generally taken once daily, with or without food, preferably at the same time each day. Swallow the tablet whole with water; do not crush, chew or alter the dose unless instructed. The usual dose of Rollosert tablet is once a day and your doctor may change the dose depending on how you respond. Take it for the full length of time prescribed. Always talk with your health care provider before starting or stopping any medication.

Side effects

Like all medicines, Rollosert 50 Tablet can cause side effects, although not everyone experiences them. Common effects may settle as the body adjusts to treatment.

Common side effects can include:

• Nausea, loose stools, or indigestion
• Headache, dizziness, tremor, or tiredness
• Trouble sleeping or daytime sleepiness
• Dry mouth and increased sweating
• Reduced appetite
• Reduced sexual desire, delayed ejaculation, or other sexual-function changes 

Seek urgent medical advice if there are signs of a serious reaction, such as severe agitation, confusion, high fever, rigid muscles, rapid heartbeat, seizures, unusual bleeding, severe rash or swelling of the face or throat. These symptoms may require immediate assessment.

Interactions

Tell your pharmacist about all prescription medicines, over-the-counter products and herbal supplements before starting Rollosert 50 Tablet.

Important interactions include:

• MAO inhibitors, including linezolid and intravenous methylene blue: do not use with sertraline or within 14 days of stopping an MAOI because of the risk of serotonin syndrome. 
• Other serotonin-increasing medicines, such as other antidepressants, tramadol, triptans for migraine, lithium, buspirone, amphetamines, tryptophan, and St John’s wort: these can increase the risk of serotonin syndrome. 
• Blood thinners and medicines that affect bleeding, including warfarin, aspirin, clopidogrel, and NSAIDs such as ibuprofen: combined use may increase bleeding risk. 
• Medicines metabolised by CYP2D6. Sertraline may affect levels of some medicines in blood so may need dose review.
• Alcohol: Alcohol should be avoided as it can increase drowsiness, dizziness and difficulty concentrating.

Pharmacokinetics

After swallowing, the controlled-release tablet releases paroxetine gradually in the digestive tract by approximately 4 hours. Peak plasma concentrations are typically achieved between 4.5 to 8.4 hours post-dose which is slower than immediate-release formulations.

The medicine is absorbed into the bloodstream and is processed mainly by the liver. It is then eliminated from the body, with about 64% of the dose being excreted via urine and roughly 36% being excreted through feces. Because paroxetine affects brain serotonin pathways and can interact with other medicines it should be used consistently and only under medical supervision. Half-life is approximately 22 to 36 hours.

Precautions

Before taking the Rollosert 50 Tablet, tell your doctor if you have:

• A history of bipolar disorder, mania or hypomania  
• Epilepsy or a history of seizures  
• Glaucoma, particularly narrow-angle glaucoma  
• Liver or kidney problems  
• Heart disease or a history of abnormal heart rhythm  
• Bleeding disorders or frequent use of blood-thinning medicines  
• Low sodium levels in the blood  
• Pregnancy, plans for pregnancy or breastfeeding  

Sertraline may cause sleepiness or dizziness in some people. Avoid driving, operating machinery or performing tasks that require full alertness until you know how the medicine affects you.

Conclusion

Rollosert 50 Tablet contains Sertraline a controlled-release, SSRI antidepressant used for depression and selected anxiety-related conditions. It may support improvement in mood and anxiety symptoms when taken regularly as prescribed but it should be used with medical supervision because individual response, side effects and medicine interactions can vary.

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