Sematrinity 4mg Pre-filled Pen

Sematrinity 4 mg prefilled pen contains semaglutide base and is used once weekly to support weight management and improve blood sugar control in adults. It is administered as a once-weekly injection. It is generally injected under the skin in your abdomen, thigh or upper arm. Eat a healthy diet and exercise regularly for best results.  

Key Features

How does Sematrinity 4 mg prefilled pen work?

Sematrinity 4 mg consists of Semaglutide which is a GLP-1 receptor agonist. GLP-1 is released in the body after eating to help regulate appetite and blood sugar levels. It slows down digestion so that the food stays in the stomach a little longer. It decreases appetite and food intake. 

Directions for use

• Inject it once a week on the same day or as prescribed by the healthcare professional. 
• Do not self-administer unless trained by a professional. 
• It can be taken with or without food. 

Dosage

Use as and when prescribed by the healthcare professional. 

Uses

• Helps improve glycemic control in Type 2 Diabetes
• Cardiovascular risk reduction
• Weight management

Side effects

Common side effects are:

• Nausea
• Stomach pain
• Diarrhea
• Vomiting 
• Constipation
• Reduced appetite

Less common side effects are:

• Bloating 
• Indigestion
• Hair loss
• Dizziness
• Burping

Serious side effects are:

• Risk of thyroid lumps
• Pancreatitis
• Hypoglycaemia
• Severe stomach problems
• Serious allergic reactions
• Vision changes

Interactions

• • Semaglutide delays stomach emptying. This alters the absorption of medications including thyroid medications, oral contraceptives, diuretics, blood pressure medications and pain relievers. 
  • Certain antibiotics and antimalarial drugs like clarithromycin, hydroxychloroquine can compound stomach side effects or alter blood sugar. 
  • Drugs like furosemide can increase the risk of dehydration.
  • Herbal supplements like gymnema, bitter melon or fenugreek if taken with Semaglutide can cause blood sugar to drop too drastically. 
  • Concomitant use of Semaglutide and Levothyroxine can reduce the absorption of thyroid medications.

• Semaglutide should be avoided with other GLP-1 agonists like Liraglutide, Tirzepatide. 

Precautions & Warnings

• Semaglutide has a warning for the risk of thyroid C-cell tumours. It should not be used in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). 
• Acute or chronic kidney damage can take place. Use with caution. 
• Avoid semaglutide if you are pregnant, planning to get pregnant or breastfeeding.
• Delayed gastric emptying can alter the absorption of oral medications taken concurrently. 
• Avoid alcohol.
• Severe vomiting or diarrhea can lead to dehydration, be cautious. 
• It can cause eye problems especially if you have a condition called diabetic retinopathy. 
• Do not use the tablet if you are allergic to Semaglutide or any other ingredient of the tablet. 
• Avoid fatty, greasy, fried and heavily spiced foods as well as sugary items as it can trigger or worsen stomach upset. 

Conclusion

Sematrinity 4 mg prefilled pen belongs to the class of Glucagon-like peptide-1 (GLP-1) receptor agonists. It works by copying the action of the natural GLP-1 hormone. Do not self-administer unless specifically trained by a healthcare professional. Its convenient once-a-week dosing makes it a convenient treatment option for many patients.

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