Danogen 100 mg is a pharmaceutical drug that is used in treating female health issues like endometriosis, fibrocystic breast disease, hereditary angioedema (HAE) by the action of danazol that may work by suppressing the pituitary ovarian axis this may result into lowering the levels of FSH (follicle stimulating hormone) and LH (Luteinizing hormone), this may reduce estrogen production.
 Key Features
| About | |
|---|---|
| Drug Class | Synthetic steroid |
| Subclass | Antigonadotropic agent |
| Active ingredient | Danazol |
| Danogen 100 mg | |
|---|---|
| Composition | Active ingredients
Inactive ingredients:
|
| Packaging Type | Blister |
| Pack Size | 3*10 |
| Dosage | 100 mg |
| Active ingredients | Danogen |
| Manufacturer | Cipla |
| Shelf Life | Two years from the date of manufacturing |
| Usages | Endometriosis, Fibrocystic breast disease, postpartum |
| Country of Origin | India |
How does Danogen 100 mg work?
- Pituitary-ovarian axis can be supressed by Danogen.
- The levels of FSH and LH may lower, this results in reducing the level of estrogen.
- It may result high-androgen and low-estrogen this may cause atrophy of endometrial tissue.
- In the condition of Hereditary angioedema (HAE) it may increases C1 esterase inhibitor levels, this may help in preventing swelling.
Usage
- It can be used in treating endometriosis.
- Fibrocystic breast disease can also be treated.
- Hereditary angioedema (HAE) can also be treated by the action of Danogen drug.
- It can also be used in dealing with premenstrual syndrome, menorrhagia, and gynecomastia.
Dosage
- It can be taken with or without food, on the same time daily
- If missed, do not doubled the dosage.
Side effects
- Weight gain
- Fluid retention
- Swelling
- Acne
- Oily skin
- Decreased breast size
- Hair loss on scalp
- Hot flushes
- Vaginal dryness
- Mood changes
- Headache
- Dizziness
- Irregular periods (Amenorrhea)
Interactions
- Danazol interacts with warfarin this may increase the anticoagulant effect also may increase the bleeding risk.
- It may interact with Carbamazepine and phenytoin adversely.
- Cyclosporin and tacrolimus may increase the hepatotoxic risk.
- When interacts with antidiabetic then it may increase the blood sugar level.
- Statins increase the risk of myopathy and rhabdomyolysis.
- Alcohol consumption is to be avoided while taking Danazol medications as it may lead to side effects like nausea, and shortness of breath.
Pharmacokinetics
- It is well absorbed orally and it may reach the peak plasma at just 2-8 hours.
- It may follow hepatic metabolism via CYP3A4 to ethisterone and other metabolites.
- Half-life is approx. 4-5 hours.
- The excretion is mainly in the form of urine and feces.
Precautions
- Pregnant and breast-feeding women should avoid taking danazol medications.
- If you are with prior medical condition of undiagnosed vaginal bleeding, severe liver, kidney, or heart disease, porphyria should avoid taking danazol medications.
Conclusion
Danogen 100 mg is a pharmaceutical drug that is used in treating female health issues like endometriosis, fibrocystic breast disease, hereditary angioedema (HAE) by the action of danazol that may work by suppressing the pituitary ovarian axis this may result into lowering the levels of FSH (follicle stimulating hormone) and LH (Luteinizing hormone), this may reduce estrogen production. It may show some side effects like weight gain, fluid retention, swelling, acne, oily skin and decreased breast size, this may vary from individual to individual and to avoid this consult your healthcare provider.
liam williams –
I had a positive experience using this and saw steady progress over time.