Metrogyl 400 Mg Tablet

Metrogyl 400 mg is an antibiotic medication that consists of metronidazole which is a nitroimidazole antibiotic. It is used to treat various bacterial and parasitic infections. It is commonly prescribed for conditions like bacterial vaginosis, trichomoniasis, amoebic dysentery, etc. 

Key Features

How does Metrogyl 400 mg work?

Metronidazole is a prodrug and it gets active only once it is in the body. It targets anaerobic organisms. Once inside the cells, the nitro group is enzymatically reduced into highly reactive cytotoxic intermediates. These reactive intermediates bind to and damage the microbe’s DNA. They cause DNA strand breakage, inhibit protein synthesis and trigger the degradation of existing nucleic acids resulting in microorganism death. 

Dosage

Use as and when prescribed by the healthcare provider. 

Substitutes

Aristogyl 400 mg

Uses

Metrogyl 400 mg is used for:

• Anaerobic bacterial infections
• Protozoal infections such as trichomoniasis, giardiasis and amoebiasis
• Bacterial vaginosis
• Surgical prophylaxis to prevent post-surgical infections
• Dental infections

Side effects 

• Agitation
• Confusion
• Dizziness
• Blurred vision
• Headache
• Nasal congestion
• Skin rashes
• Bleeding gums (rare)
• Dark urine (rare)
• Faster heartbeat (rare)
• Stomach discomfort

Interactions

• Oral anticoagulants like warfarin should not be used in combination with Metrogyl 400 mg as it can enhance the effects of the medication
• Using Metrogyl 400 mg could lead to increased levels of lithium in the body 
• Concomitant use of Metrogyl 400 mg and cyclosporine may increase the risk of cyclosporine toxicity. 
• Use Metrogyl 400 mg with extreme caution if you have any gastrointestinal issues, especially colitis as it can worsen the condition.
• Metrogyl 400 mg can worsen the risk of liver damage

Precautions & Warnings

• Do not take metronidazole if you have disulfiram within the past 2 weeks. 
• It is usually contraindicated in pregnant women
• Avoid consumption of alcohol 
• Do not take the medication if your are hypersensitive to metronidazole or any other ingredient
• Metronidazole can increase the effects of anticoagulants like warfarin
• Complete the prescribed dosage for the given duration
• If you suffer from blood dyscrasias, use this medication with caution

Conclusion

Metrogyl 400 mg is a nitroimidazole antibiotic that is used for the treatment of bacterial and parasitic infections. It is also used in combination with other antibiotics for surgical prophylaxis. The medication may not be suitable for all the people and thus informing your physician about the existing medical conditions is necessary. Use the medications under medical supervision. 

FAQs