Nirmet 500 Mg Infusion 100 ml

Nirmet 500 mg Infusion is an intravenous (IV) antibiotic medication that consists of metronidazole. It consists of 500 mg of metronidazole per 100 ml of the infusion. This IV is directly infused into the vein by a healthcare provider in a hospital or clinical setting. 

Key Features

How to use Nirmet 500 mg Infusion?

Metronidazole 500 mg/100 ml should be infused intravenously at an approximate rate of 5 ml/ minute by a healthcare provider in a hospital or clinical setting only. 

How does Nirmet 500 mg infusion work?

Nirmet 500 mg infusion consists of metronidazole which works by entering the cells of anaerobic bacteria and protozoa, where it is converted into active free radicals. These heavily reactive molecules interact with the cell’s DNA; break the DNA apart and stop protein synthesis. Due to this, eventually the cell dies. 

Uses

Nirmet infusion is used for:

• Bacterial infections
• Parasitic infections
• Surgical prophylaxis
• Combination therapy
• Vaginal health

Benefits

• Rapid action in emergencies
• Wide ranging efficacy
• Bypasses digestive issues
• Deep tissue penetration

Side effects

• Gastrointestinal issues: Nausea, vomiting, diarrhea, constipation, abdominal discomfort
• A sharp metallic taste in the mouth
• Pain, redness or burning at the site of IV
• Headache
• Dizziness
• Drowsiness
• Neurotoxicity
• Seizures (very rare)
• Jaundice (rare)
• Severe skin reactions (rare)
• Blood disorders (rare)

Interactions

• Oral anticoagulants like warfarin should not be used in combination with Nirmet 500 mg Infusion as it can enhance the effects of the medication
• Using Nirmet 500 mg Infusion could lead to increased levels of lithium in the body 
• Concomitant use of Nirmet 500 mg Infusion and cyclosporine may increase the risk of cyclosporine toxicity. 
• Epilepsy medications like phenytoin, phenobarbital can decrease the effectiveness of metronidazole
• Concomitant use of  metronidazole and QT prolonging drugs like Amiodarone can increase the risk of heart rhythm issues.
• Use Nirmet 500 mg Infusion with extreme caution if you have any gastrointestinal issues, especially colitis as it can worsen the condition.

Precautions & Warnings

• Avoid the IV if you are hypersensitive to metronidazole or any other ingredient of the infusion
• Do not consume alcohol during treatment or at least 3 days afterwards. 
• Use it with caution if you have a history of seizures or peripheral neuropathy
• The medication is strictly contraindicated in patients with Cockayne syndrome.
• Aseptic environment should be maintained throughout all the IV push procedures.
• It is not considered to be used during breastfeeding.
• The entire course of treatment should be finished even if the condition gets better. 
• Do not self-administer. 

Conclusion

Nirmet 500 mg Infusion is a nitroimidazole antibiotic that is used for the treatment of bacterial and parasitic infections. It is administered by a qualified healthcare professional in a hospital or clinical setting. 

FAQ’s